Background. Dengue disease is an acute viral illness with the common symptoms, such as: high fever, muscle and joint pain, myalgia, cutaneous rash, hemorrhagic episodes. According to the WHO, the number of cases increas ed to 390 million per year in more than 100 countries, especially in the tropical and subtropical regions.Case report. A 35 year old woman from Chisinau, Republic of Moldova presented to the Hospital of Infectious Diseases “T. Ciorba” with weakness, rash , fever 39C and pronounced sweating. The first symptoms appeared on 21.01.2016 including strong headache and fever 38.4C. Then scarlatiform maculopapular rashes occurred on the upper chest, on the sternum, and on shoulders. The eruption was red, confluent and without hemorrhagic component. On the fifth day appeared myalgia in the thoracic region and in the iliac region. On the sixth day of illness, the scarlatiform maculopapular rashes spread throughout the body. Bleeding signs were not detected. On 26th Ja nuary the patient addressed at Medpark hospital, where she had her blood tests taken and was directed to the Hospital of Infection Diseases “T. Ciorba”. Epidemiological anamnesis: on the 18th January 2016 the patient returned from Bali, Indonesia, where sh e spent 12 days with her girlfriend and girlfriend’s husband, who are from Moscow. She reported that they were bitten by mosquitoes. Exactly the same day as the patient got sick, her girlfriend started having fever and skin rash. On 27th January she addres sed to the Infectious Disease Hospital in Moscow, where the diagnosis of Dengue Fever was established to her. Laboratory investigations: General blood analysis erythrocytopenia (2.9*1012/L), leucocytopenia(2.3*109/L) and lymphocytosis (51.7%). The biochemi cal analysis of the blood didn’t show any pathological changes, as well as didn’t the general urinalysis. Conclusions. Dengue Virus belongs to the same family of Flaviviridae as Zika Virus, also both of them are tropical infections, spreaded in the same areas and transmitted by the same mosquitoes. The vaccine was developed, but it’s not available in our country so for this patient it’s important to avoid reinfection with other serotypes of the virus, which can therefore lead to the development of Dengue shock syndrome. Early diagnosis of travel imported cases is important to reduce the risk of localized outbreaks of tropical arboviruses such as Dengue Virus and the risk of local transmission from body fluids or vertical transmission.