Synthetic hydroxyapatite (HA: Ca10(PO4)6(OH)2) has been extensively used as a bone substitute material due to its chemical and structural similarity with natural bone mineral [1,2]. In the present investigation, a novel method is developed to synthesize pure, stable, stoichiometric hydroxyapatite starting from Ca(NO3)2 and the source of phosphate being a mixture of two phosphate salts, NH4H2PO4 and (NH4)2HPO4. This type of method is not mentioned in literature and it is a work in progress. Preliminary results have been obtained by using FT-IR and thermal analysis. The synthesis method was tested at different pH values, from 8 to 12, and also using Ca(CH3COO)2 as a source of calcium ions. Finally, the first method mentioned of synthesis was most preferred due to the confirmation of obtaining pure hydroxyapatite from the FT-IR spectra and the thermal analysis of the dried samples and the samples sintered at 950°C [3]. Further, we are waiting for the XRD results of the samples to confirm the crystallinity and we are in the process of adjusting the method for increasing the yield. In the future, we propose doping the hydroxyapatite with active substances and different ions in order to increase the assimilation and regeneration process in bones.figureFT-IR spectra of the synthesized sample at pH= 12 Thermogravimetric analysis of the synthesized sample at pH= 12