Mast cells as an indicator and prognostic marker in molecular subtypes of breast cancer

Carpenco Ecaterina; Ceausu Amalia-Raluca; Cimpean Anca-Maria; Gaje   Puşa Nela; Şaptefraţi Lilian; Fulga Veaceslav; David Valeriu; Raica Marius

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CARPENCO, Ecaterina, CEAUSU, Amalia-Raluca, CIMPEAN, Anca-Maria, GAJE , Puşa Nela, ŞAPTEFRAŢI, Lilian, FULGA, Veaceslav, DAVID, Valeriu, RAICA, Marius. Mast cells as an indicator and prognostic marker in molecular subtypes of breast cancer. In: In Vivo, 2019, nr. 3(33), pp. 743-748. ISSN 0258-851X. DOI: https://doi.org/10.21873/invivo.11534

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In Vivo

Numărul 3(33) / 2019 / ISSN 0258-851X

Mast cells as an indicator and prognostic marker in molecular subtypes of breast cancer

DOI:https://doi.org/10.21873/invivo.11534

Pag. 743-748

Carpenco Ecaterina¹, Ceausu Amalia-Raluca², Cimpean Anca-Maria², Gaje Puşa Nela², Şaptefraţi Lilian¹, Fulga Veaceslav¹, David Valeriu¹, Raica Marius²

¹ ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
² Victor Babes University of Medicine and Pharmacy, Timişoara

Disponibil în IBN: 27 mai 2019

Rezumat

Background/Aim: Mast cells (MCs) represent the most controversial non-malignant element of the tumor microenvironment. Our aim was to study how MCs density and distribution (intratumoral-MCit versus peritumoral-MCpt) relate to tumor grade and molecular subtypes. Materials and Methods: MCs tryptase immunohistochemistry was performed on 80 cases of breast carcinomas. Results: For Luminal A tumors, a partial correlation was detected between MCit and progesterone receptor (PR) (p=0.005). Luminal B tumors showed a significant correlation between MCpt and age (p=0.009), estrogen receptor (ER) (p=0.017) and PR (p=0.035). MCit and MCpt were strongly interrelated in this subtype (p=0.002) and in triple-negative breast cancers (p=0.002). In HER2 subtype, MCpt tumors were significantly correlated with HER2 (p=0.044). In G2 tumors, MCpt correlated with ER (p=0.015) and PR (p=0.038) while in G3 tumors ER correlated with both MCit (p=0.009) and MCpt (p=0.000487) tumors. Conclusion: MCs dynamics are strongly influenced by hormone receptors and HER2 status. MCit increased in aggressive tumor types and is a worse prognostic factor.

Cuvinte-cheie
breast cancer, Hormone receptors, mast cell, prognosis, Tryptase, Tumor grade

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