This article presents a review of the most important aspects of information security in the Republic of Moldova since the country managed to gain its independence. The analysed issues are related to this topic in the resizing context of the regional and global power relations and the contribution of the media information factor in ensuring national security. Along with the debate on what is required by the global information society and the information confrontations that take place in the regional geopolitical space, the key questions regarding information security are extensively analysed. In the end, the author offers some recommendations related to information security in the media, taking into account the Republic of Moldova’s 2019-2024 Information security strategy.