In this chapter we have aimed to demonstrate that Spirulina biomass is a suitable raw material for the manufacture of preparations containing trace elements. The natural ability of Spirulina cells to accumulate metals in the process of growth is an opportunity to obtain biomass enriched with certain trace elements. We showed here examples of biomass containing iron, zinc, chromium, copper, and selenium in much higher amounts (in some cases hundreds of times) than in biomass grown under standard conditions. A study of trace element distribution in Spirulina biomass proved that under the described conditions (administration of compounds containing trace elements in forms and concentrations non-toxic for culture) more than 80% of these are incorporated into the fractions of cellular organic compounds. Iron, zinc, chromium, and copper are linked with proteins, oligopeptides, and free amino acids. In the case of selenium only 75% of the accumulated element lies in the composition of organic substances, and a significant part is found in the lipid and carbohydrate fractions.