Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
147 0 |
SM ISO690:2012 CHESOV, Dumitru, HEYCKENDORF, Jan, ALEXANDRU, Sofia, DONICA, Ana, CHESOV, Elena, REIMANN , Maja, KRUDU, V., BOTNARU, Victor, LANGE, Christoph G.. Impact of bedaquiline on treatment outcomes of multidrug-resistant tuberculosis in a high-burden country. In: European Respiratory Journal, 2021, vol. 57, p. 0. ISSN 0903-1936. DOI: https://doi.org/10.1183/13993003.02544-2020 |
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European Respiratory Journal | |
Volumul 57 / 2021 / ISSN 0903-1936 /ISSNe 1399-3003 | |
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DOI:https://doi.org/10.1183/13993003.02544-2020 | |
Pag. 0-0 | |
Rezumat | |
Background: Evaluation of novel anti-tuberculosis (TB) drugs for the treatment of multidrug-resistant (MDR)-TB continues to be of high interest on the TB research agenda. We assessed treatment outcomes in patients with pulmonary MDR-TB who received bedaquiline-containing treatment regimens in the Republic of Moldova, a high-burden MDR-TB country. Method: We systematically analysed the SIMETB national electronic TB database and performed a retrospective propensity score-matched comparison of treatment outcomes in a cohort of patients with MDR-TB who started treatment during 2016-2018 with a bedaquiline-containing regimen (bedaquiline cohort) and a cohort of patients treated without bedaquiline (non-bedaquiline cohort). Results: Following propensity score matching, 114 patients were assigned to each cohort of MDR-TB patients. Patients in the bedaquiline cohort had a higher 6-month sputum culture conversion rate than those in the non-bedaquiline cohort (66.7% versus 40.3%; p<0.001). Patients under bedaquiline-containing regimens had a higher cure rate assessed by both World Health Organization (WHO) and TBnet definitions (55.3% versus 24.6%; p=0.001 and 43.5% versus 19.6%; p=0.004, respectively), as well as a lower mortality rate (8.8% versus 20.2%; p[removed]40% of patients achieved a cure with a bedaquiline-containing regimen. Conclusions: Bedaquiline-based MDR-TB treatment regimens result in better disease resolution when compared with bedaquiline-sparing MDR-TB treatment regimens under programmatic conditions in a country with a high burden of MDR-TB. |
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Cuvinte-cheie MeSH Antitubercular Agents, Diarylquinolines, Humans, Retrospective Studies, treatment outcome, tuberculosis, Multidrug-Resistant EMTREE drug terms amikacin, aminosalicylic acid, bedaquiline, capreomycin, Clofazimine, cycloserine, delamanid, ethambutol, ethionamide, imipenem, isoniazid, linezolid, pyrazinamide, bedaquiline, quinoline derivative, tuberculostatic agent EMTREE medical terms adult, article, clinical assessment, death, disease burden, female, fluoroquinolone resistance, human, major clinical study, Male, mortality rate, Multidrug Resistant Tuberculosis, propensity score, retrospective study, sputum culture, treatment failure, treatment outcome, treatment outcome |
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