Small and medium-sized enterprises (SMEs) are the main force for economic growth and job creation and one of the most important sectors of the economy in many countries. Like other countries, SMEs represent most businesses in the Republic of Moldova. The SMEs sector in the Republic of Moldova has grown in terms of quality and quantity over the last years. This trend may be the result of the new support programs in the field of entrepreneurship, launched by the Organization for Development of Entrepreneurship, but it may also be a result of a qualitative change of perception on the part of the business world regarding the business environment in the country. Starting from this reality, the primary aim of this research paper is to analyses the trends and challenges in SMEs development in order to provide recommendations for the SMEs' long-run development. In order to meet the aim of this research, an analysis of secondary data resources will be carried out, using scientific methods, in particular logical methods, such as comparative analysis, synthesis, induction and deduction. The research will include a macro analysis of SMEs from Republic of Moldova, based on official data from national and international bodies. The results of this research paper will make it possible to develop recommendations for improving the overall results of SMEs from the Republic of Moldova.