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SM ISO690:2012 VASILOS, Liubovi, COJOCARU, Ala, HORODIŞTEANU-BANUH, Adela, ARAMĂ, Marina, SAVOSCHIN, Dorina, CÎRSTEA (BUGA), Olga. Rolul agenţilor patogeni atipici (mycoplasma pneumoniae, chlamydia pneumoniae) şi virusului respirator syncitial în dezvoltarea obstrucţiei bronşice la copii
. In: Buletin de Perinatologie, 2012, nr. 3, pp. 7-11. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 3 / 2012 / ISSN 1810-5289 | ||||||
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Pag. 7-11 | ||||||
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Background: Asthma prevalence continues to increase all over the world, and obstructive bronchitis is one of the
most frequent manifestations of respiratory infection in children. Therefore, study of the factors that infl uence the development
and evolution of these disorders, as well as the relationship of the atopy and respiratory infections represents
important issues in pediatrics.
Material and methods: To assess the role of respiratory infections in the development of obstructive bronchitis
an epidemiological case-control study was performed at the clinical Allergy department of the Research Institute for
Maternal and Child Healthcare. The study group included 84 asthmatic children and 45 children with obstructive bronchitis
of infectious etiology. Specifi c IgA, IgM and IgG antibodies to Mycoplasma pneumoniae, Chlamydia pneumoniae
and rhinosyncytial virus were identifi ed using the enzyme-linked immunosorbent assay (ELISA).
Results: The study results showed that the seroconversion of specifi c antibodies to MPN, CPN and RSV is more
frequent in children with asthma comparing with those with obstructive bronchitis of infectious etiology (97,1% and
73,2% cases, respectively; p<0.001). Acute episode of infection caused by these microorganisms signifi cantly more
frequent were diagnosed in the group of children with asthma then in the bronchitis once (7.2% and 2.2%; 8.8% and
6.7%; 73.5% and 17.8% cases, respectively; p<0.05); chronic infections with Mycoplasma were found with the same
incidence in both groups (6.0% and 6.7% cases). A direct correlation between the level of IgG to MPN and IgE, which
is a marker of atopy (r=0.58; p<0.01), that is suggestive about de sensitization role of the Mycoplasma infection. On
the other hand an inverse correlation showed IgA levels to RSV and pulmonary function tests (r=-0.51; p<0.01), that
indicates a more severe degree of bronchial obstruction in children with RSV infection.
Conclusions: Respiratory infection, especially with Mycoplasma pneumonia and rhinosyncytial virus, triggers not
only the bronchial obstruction but is also one of the pathogenetic mechanisms in asthma exacerbations in children. This
fact must be taken into consideration when choosing therapeutic strategies for asthma management in children. |
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Cuvinte-cheie specifi c antibodies, Mycoplasma pneumoniae (MPN), Chlamydia pneumoniae (CPN), rhinosyncytial virus (RSV), respiratory diseases |
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