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Ultima descărcare din IBN: 2024-04-19 12:48 |
SM ISO690:2012 BALUTEL, Tatiana, CIUNTU, Angela, REVENCO, Ninel. The role of oxidative stress in chronic kidney disease in children. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 407. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 407-407 | ||||||
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Background. Oxidative stress (OS) is an imbalance between the production and elimination of reactive oxygen species (ROS). The kidney, as an organ with intense mitochondrial activity, becomes extremely vulnerable to the lesions caused by ROS with the subsequent progression to chronic kidney disease (CKD). Objective of the study. Studying the role of so in the etiopathogenetic mechanisms of CKD in children. Material and methods. The study is based on the analysis of bibliographic sources published in the PubMed, ResearchGate, Elsevier, PlosOne database between 2018 and 2022. Results. The consequences of OS are inflammation and endothelial dysfunction, with impaired renal function. Oxidative markers such as plasma isoprothanes F2, advanced oxidation protein products, malondialdehyde, and oxidized LDL (Ox-LDL) have increased levels in CKD. Worsening of OS in CKD is caused by increased activity of nicotinamide adenine dinucleotide phosphate oxidase (NADPH) (NOx), increased xanthinoxidase and mitochondrial dysfunction. Hemodialysis carries additional risks responsible for the pro-oxidant state in patients with CKD, by eliminating antioxidant substances, the presence of residual endotoxins from dialysis, and the hemoincompatibility of the dialysis system. Conclusion. OS by vascular lesions directly affects the nephron at all levels with deterioration/loss of renal function and progression of CKD. Oxidative damage, in turn, is aggravated by uremia, hemodialysis system and concomitant comorbidities of patients with CKD. |
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Cuvinte-cheie oxidative stress, marker, chronic kidney disease, stres oxidativ, marker, boala cronică renală |
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