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SM ISO690:2012 VASILIEV, Vladislav. Renal stones chemical composition in patient with recurrent nephrolithiasis in the Republic of Moldova: an experimental study. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 341. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 341-341 | ||||||
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Introduction: The prevalence of urolithiasis is increasing in both developed and developing countries. Studies have demonstrated that ethnicity, geographic region, and living conditions could have an influence on stone formation. The prevalence and incidence of urolithiasis vary among different countries and races and between the sexes. The lifetime incidence of urolithiasis in Middle Eastern and Western countries is 25% and 10%, respectively. However, the recurrence rates are high, reaching 50% worldwide. The regional peculiarities of chemical composition of kidney stones have its significance in management of the urinary lithiasis. Aim of study: The study aims to research the chemical composition of renal and ureteric calculi in recurrent kidney stone formers. Material and methods: The study was performed in the clinic of Urology and Surgical Nephrology of Nicolae Testimițanu SUMPh, „T. Mosneaga” RCH between January 1, 2016-2021. There were 116 kidney stones analyzed; the researched material was sent to the Institute of Chemistry. The Fourier Spectrum 100 FT-IR transform infrared spectrometer (PerkinElmer, USA) was used to determine the composition of urinary stones. The spectra were recorded with the ATR accessory (attenuated total reflection) and the identification of the calculations was performed by comparing the experimental spectra with the spectra in the literature. Results: The most common were calcium oxalate calculi (total – 50 (43.1%); whewellite - 41 (35.34%); weddelite – 9 (7.76%), followed in frequency by uric acid (19, (16.38%). Phosphate calculi were identified in 14 (12.07%) cases, and contained: calcium phosphate - 7 (6.03%), struvite – 4 (3.45%), brushite - 1 (0.86%) cases. Calculi of cistine - 3 (2.59%). In 30 (25.86%) cases were identified stones of mixed composition. Other varieties of calculi were less common. Conclusions: The microstructure of the stone matrix varies among the stone types and is determined by the mineral composition. The compositional analysis reveals the mineral types responsible for the stone formation, and the ultra-structural investigation of kidney stone matrix provide additional details that are crucial links to the pathogenesis. Calcium oxalate, uric acid, and mixed uric acid and calcium oxalate calculi are the main types in Moldova. We feel such data would help in providing precise treatment and efficient metaphylaxis. |
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Cuvinte-cheie urolithiasis, renal stones, chemical composition of stones, urolitiază, calculi renali, structura calculilor |
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