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616.98:578.834:616.36-002-036-02 (1) |
Communicable diseases. Infectious and contagious diseases, fevers (587) |
Virology (446) |
Pathology of the digestive system. Complaints of the alimentary canal (1819) |
![]() MALANCEA, Olesea, ȘTÎRBA, Dumitru, LATUS, Svetlana. SARS-CoV-2 infection and the liver. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 55. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.98:578.834:616.36-002-036-02 | ||||||
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Background. SARS-CoV-2 infection can alter the function of all organs and systems, including the liver. Liver damage ranges from 14% to 53%, especially in patients with pre-existing liver disease and treated with hepatotoxic preparations. Objective of the study. Determination of the mechanisms, parameters and degrees of liver function impairment in patients with SARS-CoV-2. Material and Methods. A retrospective analysis of 50 medical prescription sheets of patients with SARS-CoV-2, hospitalized in the Arhanghelul Mihail MCH was performed. The values of transaminases, ALP, GGT, LDH, and bilirubin were analyzed. The prescribed treatment and the identification of drugs metabolized in the liver or with known hepatotoxicity-paracetamol, macrolides, lopinavir/ritonavir, chloroquine/hydroxychloroquine, remdesivir, tocilizumab, corticosteroids were analyzed. Results. The increase in ALT and AST occurred in 15 patients, and the evaluation of cytolytic syndrome showed minimal activity in 4 patients and moderate in 11 patients. Biochemical markers of cholestatic syndrome indicated abnormal values in 19 patients, 2-had increased bilirubin levels, 4-had increased levels of ALP and GGT, and 15-presented only elevation of GGT. The analysis of the treatment showed that 11 patients administered 5-10 drugs, and 39 patients (78%)more than 10 drugs. Conclusion. Liver damage in patients with Covid-19 may be due to direct viral action, hypoxic state, cytokine storm, and may be caused by anti-Covid medication. Markers of liver function denote cytolytic syndrome with a predominantly moderate degree of activity, as well as the development of the cholestatic syndrome. |
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Cuvinte-cheie SARS-CoV-2, liver, hepatitis, SARS-CoV-2, Ficat, hepatită |
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