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Ultima descărcare din IBN: 2024-02-07 20:53 |
Căutarea după subiecte similare conform CZU |
616.853-08 (12) |
Neurology. Neuropathology. Nervous system (971) |
SM ISO690:2012 OLARU, Natalia, AFTENE, Daniela, IUHTIMOVSCHI, Liliana. Neuromodulation in the treatment of drug-resistant epilepsy. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 275. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.853-08 | ||||||
Pag. 275-275 | ||||||
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Introduction. Despite the availability of a wide range of anticonvulsant medications, however, 30% of patients with epilepsy continue to have seizures, which exposes them to various traumas that affect their quality of life, increases the risk of comorbidities and sudden death in epilepsy. Objective of the study: To evaluate the efficacy of VNS (vagus nerve stimulation), TMS (transcranial magnetic stimulation) and FUS (focused ultrasound) methods in patients with drug-resistant epilepsy. Material and Methods. Scientific articles from the PubMed databases, Scopus on clinical trials and meta-analyzes published during 2014-2022 were analyzed. Effectiveness was assessed by reducing the frequency of seizures and the seizure-free period. Results. VNS studies report a 34.7% decrease in seizure frequency. Statistical analyzes have shown a reduction in seizures and interictal epileptic discharges when applying low-frequency TMS. However, the effectiveness of the anticonvulsant decreased in a few weeks, suggesting that TMS has a short-term effect. In a study of six patients who underwent FUS, two patients had a decrease in seizures in 3 days post-therapy. However, one patient showed frequent signs of subclinical seizures. Conclusion. Neuromodulation is an alternative treatment method for drug-resistant epilepsy, which is under study and implementation. Compared to current methods of treatment, FUS can access the deep regions of the brain and remove the main epileptic network in a less invasive way. Long-term studies encourage the application of VNS, TMS and are in progress for FUS. |
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Cuvinte-cheie epilepsy, Drug-resistance, neuromodulation, epilepsie, farmacorezistență, neuromodulare |
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