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Ultima descărcare din IBN: 2023-06-26 16:04 |
Căutarea după subiecte similare conform CZU |
611.018.1+57.085.23 (1) |
Anatomy. Human and comparative anatomy (240) |
Biological techniques, experimental methods and equipment in general (199) |
![]() GLOBA, Lilian. Endoglin (CD105) expression by mesenchimal stem cells from human placenta and umbilical cord . In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 9. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 611.018.1+57.085.23 | ||||||
Pag. 9-9 | ||||||
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Background. Endoglin is expressed by mesenchymal stem cells. It is important for the development of hemangioblasts. The role of endoglin is to preserve the potential of mesenchymal stem cells versus the differentiation of colony-forming precursor cells. Objective of the study. Identification of the angioblastic potential of mesenchymal stem cells from the placenta and umbilical cord using immunohistochemical staining with the anti-CD105 marker. Material and Methods. The research is based on bibliographic sources that were analyzed using PubMed, NCBI and Medline published within the period of 2012-2022. Immunohistochemical evaluation included marker for endoglin anti-CD105. Results. Mesenchymal stem cells are the precursors of connective tissue cells. The ability of these cells to differentiate into osteoblasts, adipocytes, chondroblasts, and other cell types allows them to be used successfully as cell grafts in the tissue engineering. Mesenchymal stem cells of the placenta, nonvascular amnion and perivascular tissue of the umbilical cord have shown a strong proangiogenic effect. Endoglin (CD105) is a membrane glycoprotein expressed by endothelial cells that binds TGF-β1 with high affinity. TGF-β is an important protein involved in the vascular remodeling, with both an agonist and an antagonist effect in angiogenesis. Conclusion. Mesenchymal stem cells play a key role in the vessel stabilization and are involved in angiogenesis and vasculogenesis. Mesenchymal stem cells could be important for angiogenesis stimulating in various ischemic tissues. |
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Cuvinte-cheie mesenchymal stem cells, endoglin, placenta, umbilical cord, celule stem, mezenchimale, endoglină, placenta, cordon ombilical |
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