Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy
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2023-11-07 22:15
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AMĂRIUCĂI-MANTU, Dorina, MANGALAGIU, Violeta, BEJAN, Iustinian Gabriel, ARICU, Aculina, MANGALAGIU, Ionel I.. Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy. In: Pharmaceutics, 2022, nr. 10(14), pp. 1-41. ISSN 1999-4923. DOI: https://doi.org/10.3390/pharmaceutics14102026
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Pharmaceutics
Numărul 10(14) / 2022 / ISSN 1999-4923

Hybrid Azine Derivatives: A Useful Approach for Antimicrobial Therapy

DOI:https://doi.org/10.3390/pharmaceutics14102026

Pag. 1-41

Amăriucăi-Mantu Dorina1, Mangalagiu Violeta21, Bejan Iustinian Gabriel12, Aricu Aculina13, Mangalagiu Ionel I.12
 
1 Alexandru Ioan Cuza University of Iaşi,
2 Institute of Interdisciplinary Research – CERNESIM Centre,
3 Institute of Chemistry
 
 
Disponibil în IBN: 14 noiembrie 2022


Rezumat

 Nowadays, infectious diseases caused by microorganisms are a major threat to human health, mostly because of drug resistance, multi-drug resistance and extensive-drug-resistance phenomena to microbial pathogens. During the last few years, obtaining hybrid azaheterocyclic drugs represents a powerful and attractive approach in modern antimicrobial therapy with very promising results including overcoming microbial drug resistance. The emphasis of this review is to notify the scientific community about the latest recent advances from the last five years in the field of hybrid azine derivatives with antimicrobial activity. The review is divided according to the main series of six-member ring azaheterocycles with one nitrogen atom and their fused analogs. In each case, the main essential data concerning synthesis and antimicrobial activity are presented.

Cuvinte-cheie
Antimicrobial, fused azine, hybrid compounds, isoquinoline, Pyridine, quinoline