Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19
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BEGHI, Ettore, HELBOK, Raimund, OZTURK, Serefnur, KARADAS, Omer, LISNIC, Vitalie, GROSU, Oxana, KOVACS, Tibor, DOBRONYI, Levente, BERECZKI, Daniel, COTELLI, Maria Sofia, TURLA, Marinella, DAVIDESCU, Eugenia Irene, POPESCU, Bogdan Ovidiu, VALZANIA, Franco, CAVALLIERI, Francesco, ULMER, Hanno, MAIA, Luis Filipe, AMODT, Anne Hege, ARMON, Carmel, BROLA, Waldemer, GRYB, Victoria, RIAHI, Anis, KREHAN, Ingomar, VON OERTZEN, Tim, AZAB, Mohammed A., CREAN, Michael, LOLICH, Maria, LIMA, Maria Joao, SELLNER, Johann, PERNECZKY, Julian, JENKINS, Thomas Michael, MEONI, Sara, BIANCHI, Elisa, MORO, Elena, BASSETTI, Claudio L. A., URAL, Onur, KARA, Iskender, OZTURK, Bilgin, GAVRILIUC, Mihail, ODAINIC, Olesea, CIVELLI, Patrizia, BIANCHI, Marta, BUNEA, Teodora, SANDU, Georgiana, TOSCHI, Giulia, OLIVEIRA, Vanessa, DIAS, Alexandre, JUNG, Simon, HOEPNER, Robert, BOLDINGH, Marion Ingeborg, AGAJANY, Netta, WOLFSON, Sharon, LIPOWSKI, Michal, LESIV, Marjiana, DERBALI, Hajer, SEABRA, Mafalda Maria Laracho, CARVALHO, Vanessa, FLEMMEN, Heidi Oyen, YASUDA, Clarissa Lin, TABA, Pille, YASSIN, Osama, KITEVA-TRENCHEVSKA, Gordana. Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19. In: European Journal of Neurology, 2022, nr. 6(29), pp. 1663-1684. ISSN 1351-5101. DOI: https://doi.org/10.1111/ene.15293
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European Journal of Neurology
Numărul 6(29) / 2022 / ISSN 1351-5101 /ISSNe 1468-1331

Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19
DOI:https://doi.org/10.1111/ene.15293

Pag. 1663-1684

Beghi Ettore1, Helbok Raimund2, Ozturk Serefnur3, Karadas Omer4, Lisnic Vitalie5, Grosu Oxana56, Kovacs Tibor7, Dobronyi Levente7, Bereczki Daniel8, Cotelli Maria Sofia9, Turla Marinella9, Davidescu Eugenia Irene10, Popescu Bogdan Ovidiu11, Valzania Franco12, Cavallieri Francesco12, Ulmer Hanno2, Maia Luis Filipe13, Amodt Anne Hege14, Armon Carmel15, Brola Waldemer16, Gryb Victoria17, Riahi Anis18, Krehan Ingomar19, von Oertzen Tim20, Azab Mohammed A.21, Crean Michael22, Lolich Maria22, Lima Maria Joao23, Sellner Johann24, Perneczky Julian25, Jenkins Thomas Michael26, Meoni Sara27, Bianchi Elisa1, Moro Elena28, Bassetti Claudio L. A.29, Ural Onur3, Kara Iskender30, Ozturk Bilgin31, Gavriliuc Mihail32, Odainic Olesea32, Civelli Patrizia33, Bianchi Marta34, Bunea Teodora10, Sandu Georgiana10, Toschi Giulia12, Oliveira Vanessa13, Dias Alexandre35, Jung Simon29, Hoepner Robert29, Boldingh Marion Ingeborg36, Agajany Netta15, Wolfson Sharon37, Lipowski Michal16, Lesiv Marjiana16, Derbali Hajer38, Seabra Mafalda Maria Laracho39, Carvalho Vanessa40, Flemmen Heidi Oyen41, Yasuda Clarissa Lin42, Taba Pille43, Yassin Osama16, Kiteva-Trenchevska Gordana44
 
1 IRCCS - 'Mario Negri' Institute for Pharmacological Research, Milan,
2 Medical University Innsbruck,
3 Selcuk University, Konya,
4 University of Health Sciences, Turkey,
5 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
6 Academy of Sciences of Moldova,
7 Semmelweis University,
8 University of Debrecen,
9 Valle Camonica Hospital, Esine, Brescia,
10 Colentina Clinical Hospital,
11 University of Medicine and Pharmacy “Carol Davilla”, Bucharest,
12 USL-IRCCS company of Reggio Emilia, Reggio Emilia,
13 Porto Hospital and University Center, Porto,
14 Oslo University Hospital,
15 Tel Aviv University School of Medicine, Tel Aviv,
16 Jan Kochanowski University of Kielce,
17 Ivano-Frankivsk National Medical University,
18 Military Hospital of Tunis,
19 Kepler University Hospital Linz,
20 Tunis El Manar University,
21 Idaho State University, Boise,
22 European Academy of Neurology,
23 Pedro Hispano Hospital, Porto,
24 European Association of Young Neurologists and Trainees (EAYNT), Austria,
25 Mistelbach-Ganserndorf State Hospital, Mistelbach,
26 The University of Sheffield Institute for Translational Neuroscience, Sheffield,
27 Grenoble Alpes University Hospital Center,
28 Grenoble Alpes University,
29 University Hospital Bern,
30 Gazi University,
31 Baskent University Hospital Izmir,
32 Diomid Gherman Institute of Neurology and Neurosurgery,
33 Center for Neuromuscular Diseases, Brescia,
34 ASST Della Valcamonica, Breno,
35 University of Porto,
36 Academisch Ziekenhuis Leiden - Leids Universitair Medisch Centrum,
37 Tel Aviv University,
38 University of Tunis El Manar, Tunis,
39 E.P.E, Porto, Spain,
40 Egas Moniz Study Center, Lisbon,
41 Telemark Trust Hospital, Skien,
42 State University of Campinas – Unicamp,
43 University of Tartu, Estonia,
44 Ss. Cyril and Methodius University in Skopje
 
 
Disponibil în IBN: 11 noiembrie 2022
Rezumat

 Background and purpose: Despite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short- and long-term outcome of the disease. Methods: This is a cohort study enrolling adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the European Academy of Neurology NEuro-covid ReGistrY ((ENERGY). The outcome at discharge was measured using the modified Rankin Scale and defined as ‘stable/improved’ if the modified Rankin Scale score was equal to or lower than the pre-morbid score, ‘worse’ if the score was higher than the pre-morbid score. Status at 6 months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6 months. Results: From July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor/coma, stroke and intensive care unit (ICU) admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor/coma and ICU admission were associated with death. 262 were followed for 6 months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65/221 hospitalized patients (29.4%) and 10/32 non-hospitalized patients (24.4%) experienced persisting neurological symptoms/signs. 10/262 patients (3.8%) developed new neurological complaints during the 6 months of follow-up. Conclusions: Neuro-COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection. 
Cuvinte-cheie
COVID-19, neurological disorders, Outcome, predictors, SARS-CoV-2

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<titles>
<title xml:lang='en'>Short- and long-term outcome and predictors in an international cohort of patients with neuro-COVID-19</title>
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<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2022</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1351-5101</relatedIdentifier>
<subjects>
<subject>COVID-19</subject>
<subject>neurological disorders</subject>
<subject>Outcome</subject>
<subject>predictors</subject>
<subject>SARS-CoV-2</subject>
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<dates>
<date dateType='Issued'>2022-02-23</date>
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<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
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<description xml:lang='en' descriptionType='Abstract'><p>&nbsp;</p><p>Background and purpose: Despite the increasing number of reports on the spectrum of neurological manifestations of COVID-19 (neuro-COVID), few studies have assessed short- and long-term outcome of the disease. Methods: This is a cohort study enrolling adult patients with neuro-COVID seen in neurological consultation. Data were collected prospectively or retrospectively in the European Academy of Neurology NEuro-covid ReGistrY ((ENERGY). The outcome at discharge was measured using the modified Rankin Scale and defined as &lsquo;stable/improved&rsquo; if the modified Rankin Scale score was equal to or lower than the pre-morbid score, &lsquo;worse&rsquo; if the score was higher than the pre-morbid score. Status at 6&nbsp;months was also recorded. Demographic and clinical variables were assessed as predictors of outcome at discharge and 6&nbsp;months. Results: From July 2020 to March 2021, 971 patients from 19 countries were included. 810 (83.4%) were hospitalized. 432 (53.3%) were discharged with worse functional status. Older age, stupor/coma, stroke and intensive care unit (ICU) admission were predictors of worse outcome at discharge. 132 (16.3%) died in hospital. Older age, cancer, cardiovascular complications, refractory shock, stupor/coma and ICU admission were associated with death. 262 were followed for 6&nbsp;months. Acute stroke or ataxia, ICU admission and degree of functional impairment at discharge were predictors of worse outcome. 65/221 hospitalized patients (29.4%) and 10/32 non-hospitalized patients (24.4%) experienced persisting neurological symptoms/signs. 10/262 patients (3.8%) developed new neurological complaints during the 6&nbsp;months of follow-up. Conclusions: Neuro-COVID is a severe disease associated with worse functional status at discharge, particularly in older subjects and those with comorbidities and acute complications of infection.&nbsp;</p></description>
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