Introduction: Skin tag (ST, acrohordon, fibroepithelial polyp) is the most common fibrous lesion of the skin and presents as a soft, pedunculated, skin-colored papule (1-2mm). Multiple acrohordons may reflect obesity and endocrine disease, whereas solitary and larger lesions may occasionally represent dermal melanocytic nevi in regression. Patients and methods: Results were obtained from two independent series in an urban area outpatient setting of a general state hospital dermatologic teaching clinic. At first, an eight-year cross sectional data (1995-2002) regarding lifetime detection rates of ST as presenting complaint. All cases entered in the study were first time referrals. The overall denominator and reference population consisted of 50,237 self referred Greek dermatologic outpatients, Mantel-Haenszel chi-square stratified analysis was used to compare detection rates by age and gender without confounding effects]. The second series (n=787) included 204 total cases of ST (25.9%) and possible associations with body mass index (BMI, for obesity) and diabetes mellitus were investigated. Results and discussion: Overall and by age group both sexes were equally affected. From adolescence up to 40 years a significant increment by age was noted. From 41 to 70 years highest detection rates were detected. Thereafter diagnoses began to decline, probably because in the elderly aesthetic concerns are overlooked. For both sexes peak prevalence was observed in the age group from 41 to 50 years. In the second series, BMI did not differ between ST cases and the remaining without ST patient population (mean±SEM, unpaired t-test, n=204, 27.7±0.35 and n=583, 29.4±3.03) contrary to “classic” opinions. In ST cases a positive history of diabetes was reported from 7.8% (16/204) versus 9.1% (53/583) from the remaining non-ST population. The lack of difference as regards diabetes mellitus frequency (chi-square) is opposed to a previously held opinion and reinforces another report that has not confirmed this association. The problem is overlooked, since perceived disease duration differed significantly between ST cases and the remaining skin diseases [mean±SEM; unpaired ttest, n=202, 5.8±0.35 years (range, 1 month-30 years) vs. n=580, 4.06±0.26 years (range, 0.0-65), p=0.0004].