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SM ISO690:2012 TOFAN, Elena, BUTOROV, Ivan, GONCIAR, Veaceslav, BUTOROV, Serghei, NECULA, Gheorghe, SCUTAR, Corina. Metodă contemporană de tratament al insuficienţei cardiace cronice cu fracţie de ejecţie diminuată. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 3(12), pp. 74-78. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(12) / 2011 / ISSN 1857-1719 | ||||||
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Pag. 74-78 | ||||||
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Dinamics of the ecocardiographic and hemodynamic parameters under
the influence of lisinopril, losartan and their association
The aim of the study was to appreciate the effects of the ACE inhibitor lisinopril, AT-I
receptors inhibitor losartan and their combination on the dynamics of the main
ecocardiographical, hemodynamical and neurohormonal parameters in 65 patients with chronic
heart failure with the ejection fraction of the left ventricle less then 45%. In all three groups, the
administrated therapy determined a partial resolution of the dispnoea, peripheral edemas and
increase of the tolerance to physical work, but the combined therapy hurried these effects by 3-4
days sooner then in monotherapy. At the end of the treatment period, the functional class of the
CHF decreased in patients taking lisinopril by 25,8%; losartan – by 28,1% and their association –
by 36,4%, while the ejection fraction of the left ventricle increased by 26,8%, 17,2% and 40,1%,
respectively. |
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<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Tofan, E.</dc:creator> <dc:creator>Butorov, I.V.</dc:creator> <dc:creator>Gonciar, V.I.</dc:creator> <dc:creator>Butorov, S.</dc:creator> <dc:creator>Necula, G.</dc:creator> <dc:creator>Scutar, C.D.</dc:creator> <dc:date>2011-06-01</dc:date> <dc:description xml:lang='en'>Dinamics of the ecocardiographic and hemodynamic parameters under the influence of lisinopril, losartan and their association The aim of the study was to appreciate the effects of the ACE inhibitor lisinopril, AT-I receptors inhibitor losartan and their combination on the dynamics of the main ecocardiographical, hemodynamical and neurohormonal parameters in 65 patients with chronic heart failure with the ejection fraction of the left ventricle less then 45%. In all three groups, the administrated therapy determined a partial resolution of the dispnoea, peripheral edemas and increase of the tolerance to physical work, but the combined therapy hurried these effects by 3-4 days sooner then in monotherapy. At the end of the treatment period, the functional class of the CHF decreased in patients taking lisinopril by 25,8%; losartan – by 28,1% and their association – by 36,4%, while the ejection fraction of the left ventricle increased by 26,8%, 17,2% and 40,1%, respectively.</dc:description> <dc:description xml:lang='ro'>Scopul studiului a fost de a studia eficienţa inhibitorului ECA lisinopril, a inhibitorului receptorilor AT-I losartan şi asocierii lor asupra evoluţiei indicilor ecocardiografici, hemodinamici şi neurohormonali la 72 de pacienţi cu insuficienţă cardiacă cronică şi fracţia de ejecţie a ventriculului stâng mai mică de 45%. Tratamentul administrat a determinat abolirea parţială a dispneei, a edemelor periferice şi majorarea toleranţei la efort fizic, însă terapia asociată a grăbit aceste efecte cu 3-4 zile în comparaţie cu monoterapia. La finele perioadei de tratament la bolnavii care au administrat lisinopril clasa funcţională a ICC a diminuat cu 25,8%, losartan – cu 28,1% şi asocierea lor – cu 36,4%, iar FE a VS s-a majorat cu 26,8%, 17,2% şi 40,1%, respectiv.</dc:description> <dc:source>Analele Ştiinţifice ale USMF „N. Testemiţanu” 12 (3) 74-78</dc:source> <dc:title>Metodă contemporană de tratament al insuficienţei cardiace cronice cu fracţie de ejecţie diminuată</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>