Metodă contemporană de tratament al insuficienţei cardiace cronice cu fracţie de ejecţie diminuată

Tofan Elena; Butorov Ivan; Gonciar Veaceslav; Butorov Serghei; Necula Gheorghe; Scutar Corina

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2024-01-10 20:40

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TOFAN, Elena, BUTOROV, Ivan, GONCIAR, Veaceslav, BUTOROV, Serghei, NECULA, Gheorghe, SCUTAR, Corina. Metodă contemporană de tratament al insuficienţei cardiace cronice cu fracţie de ejecţie diminuată. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 3(12), pp. 74-78. ISSN 1857-1719.

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Analele Ştiinţifice ale USMF „N. Testemiţanu”

Numărul 3(12) / 2011 / ISSN 1857-1719

Metodă contemporană de tratament al insuficienţei cardiace cronice cu fracţie de ejecţie diminuată

Pag. 74-78

Tofan Elena, Butorov Ivan, Gonciar Veaceslav, Butorov Serghei, Necula Gheorghe, Scutar Corina

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“

Disponibil în IBN: 16 decembrie 2013

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Dinamics of the ecocardiographic and hemodynamic parameters under the influence of lisinopril, losartan and their association The aim of the study was to appreciate the effects of the ACE inhibitor lisinopril, AT-I receptors inhibitor losartan and their combination on the dynamics of the main ecocardiographical, hemodynamical and neurohormonal parameters in 65 patients with chronic heart failure with the ejection fraction of the left ventricle less then 45%. In all three groups, the administrated therapy determined a partial resolution of the dispnoea, peripheral edemas and increase of the tolerance to physical work, but the combined therapy hurried these effects by 3-4 days sooner then in monotherapy. At the end of the treatment period, the functional class of the CHF decreased in patients taking lisinopril by 25,8%; losartan – by 28,1% and their association – by 36,4%, while the ejection fraction of the left ventricle increased by 26,8%, 17,2% and 40,1%, respectively.

Scopul studiului a fost de a studia eficienţa inhibitorului ECA lisinopril, a inhibitorului receptorilor AT-I losartan şi asocierii lor asupra evoluţiei indicilor ecocardiografici, hemodinamici şi neurohormonali la 72 de pacienţi cu insuficienţă cardiacă cronică şi fracţia de ejecţie a ventriculului stâng mai mică de 45%. Tratamentul administrat a determinat abolirea parţială a dispneei, a edemelor periferice şi majorarea toleranţei la efort fizic, însă terapia asociată a grăbit aceste efecte cu 3-4 zile în comparaţie cu monoterapia. La finele perioadei de tratament la bolnavii care au administrat lisinopril clasa funcţională a ICC a diminuat cu 25,8%, losartan – cu 28,1% şi asocierea lor – cu 36,4%, iar FE a VS s-a majorat cu 26,8%, 17,2% şi 40,1%, respectiv.

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the influence of lisinopril, losartan and their association
The aim of the study was to appreciate the effects of the ACE inhibitor lisinopril, AT-I
receptors inhibitor losartan and their combination on the dynamics of the main
ecocardiographical, hemodynamical and neurohormonal parameters in 65 patients with chronic
heart failure with the ejection fraction of the left ventricle less then 45%. In all three groups, the
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increase of the tolerance to physical work, but the combined therapy hurried these effects by 3-4
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