This article constitutes a comprehensive analysis of the institutional interaction through the paradigm of the investigation of offences of illicit enrichment involving new outlines and theoretical and practical development interests, as this subject, over the years, has not received due scientific attention in the criminalistic literature from the Republic of Moldova. This tendency is part of the international arena to transform and adapt the methods and processes aimed at creating legal instruments to be made available to the institutions responsible for the efficient investigation of offences of illegal enrichment. This is largely due, on the one hand, to the progress and international standard achieved and, on the other hand, to the community’s willingness to harmonize the national framework with that standard, which establishes the preeminence of law subscribed to the rule of law and the supremacy of law.