The comparative analysis of the drug resistance of mbtin children, adolescents and the sources of infection in the multidrug resistant tuberculosis focies
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616.24-002.5-085.28:615.015.8]-053.5/.6 (1)
Pathology of the respiratory system. Complaints of the respiratory organs (757)
Pharmacology. Therapeutics. Toxicology (1592)
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SAKHELASHVILI-BIL, Olha, SAKHELASHVILI, Manana. The comparative analysis of the drug resistance of mbtin children, adolescents and the sources of infection in the multidrug resistant tuberculosis focies. In: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale, 2021, nr. 3(71), pp. 234-238. ISSN 1857-0011. DOI: https://doi.org/10.52692/1857-0011.2021.3-71.18
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Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale
Numărul 3(71) / 2021 / ISSN 1857-0011

The comparative analysis of the drug resistance of mbtin children, adolescents and the sources of infection in the multidrug resistant tuberculosis focies

Сравнительная характеристика лекарстенной устойчивости МБТ у детей, подростков и источника инфекции в очагах мультирезистеного туберкулеза

Analiza comparativă a rezistenței la medicamente a copiilor, adolescenților și a surselor de infecție în focarele de tuberculoză multirezistentă

DOI:https://doi.org/10.52692/1857-0011.2021.3-71.18
CZU: 616.24-002.5-085.28:615.015.8]-053.5/.6

Pag. 234-238

Sakhelashvili-Bil Olha, Sakhelashvili Manana
 
Danylo Halytsky Lviv National Medical University
 
 
Disponibil în IBN: 19 ianuarie 2022


Rezumat

145 patients (67 children and 78 adolescents) from the multidrug-resistant tuberculosis infection focies took part in the complex microbiological study. The children and adolescents had undergone treatment for the pulmonary multidrugresistant tuberculosis. The study showed that MDR TB was by 1.7 times more often revealed in the adolescents as compared to the children, while the risk of MDR TB was by 3.7 times higher for the children than for the adolescents. The drug resistance profile of the children and the sources of infection almost completely coincided. The resistance to HRSE (66.1%) and HRESZ (13.6%) developed in the adolescents more often than in the children and adults. The study proves the importance of defining the drug resistance profile in the exposed children and adolescents from the multidrugresistant tuberculosis focies.

Проведено комплексное микробиологическое обследование 145 детей (67) и подростков (78) из очагов мультирезистентной туберкулезной инфекции. Дети и подростки лечились в связи с мультирезистентным туберкулезом легких (МРТБ). Установлено, что у подростков МРТБ отмечается в 1,7 раза чаще, чем у детей, а риск к МРТБ – в 3,7 раза чаще у детей, чем подростков. У детей констатировано полное совпадение характера устойчивости с источником инфекции, а у подростков чаще всего резистентность отмечено к комбинации HRSE (66,1%) HRESZ (13,6%), в отличии взрослых и детей. Проведенная робота доказывает важность определения профиля резистентности у контактных детей и подростков из очагов мультирезистентной туберкулезной инфекции.

Cuvinte-cheie
MRTB, children, adolescents,

МРТБ, дети, подростки