Marine invertebrates are commonly and routinely used as bioindicators of water pollution, as biomarkers evaluated from them serve as important biomonitoring tools and as indicators for the presence of toxic products in polluted environments, such as coastal and estuarine areas. The effect of pollutants on marine biota, including mussels, as model organisms, can be evaluated by routinely measuring oxidative stress levels. This is currently accomplished by integrating biochemical assays of different antioxidant defence enzymes, including superoxide dismutase (SOD) and catalase (CAT). In this paper we provide a comparative analysis regarding the arguable interpretation of the results from several different studies, which employed assays of SOD, CAT, alongside with evaluation of the lipid peroxidation (LP), in order to evaluate coastal pollution using mussels. Afterwards, we provide a specific set of reasons that could underlie the arguable efficiency of antioxidant enzymes from mussels to evaluate the level of water pollution and degradation of coastal ecosystems and we present some suitable alternatives. Thus, the study argues a novel viewpoint which, in our opinion, merits further consideration in the developing field of marine biomonitoring. The proteins like albumins, globulins and glutelins could be efficient biomarkers. Finally, has been reiterated the importance of the mussels in the marine ecosystem aiming their capacity to purify the water by filtration. The experimental scientific manifestations to the level of consortium team (preuniversity-university) is emphasizing this eco-role. Besides this criterion, we support that Mytilus galloprovincialis is also an eatable mollusc, for accreditation (through its potential nutrition) and in Romania, of the successful development of the mussel marine culture in line with variations in the marine environment -as an alternative potential source of food. The final idea is of achievement and expansion of the mussel eco-mariculture in certain landmark easily accessible to the Black Sea seaside.