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![]() BURAC, Mihaela, FRIPTU, Valentin, COROLCOVA, Natalia. Influența statutului imun endometrial asupra fertilității. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 603. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. The endometrial immune axis is the elucidation of major problems in female reproductive health, especially in infertility. Current research has identified cytokines as molecular markers responsible for the tolerance and immunity of the female reproductive tract. Objective of the study. Evaluation of pro- and anti-inflammatory cytokine levels in endometrial fluid in patients with primary infertility. Material and Methods. A prospective cohort study was performed, which included 96 patients divided into study group (L1) - 48 patients with primary infertility and control group (L0) 48 fertile patients. The endometrial fluid was aspirated with the Pipelle suction curette. Statistical analysis was performed using SPSS 20 and Microsoft Excel 2016. Results. The mean age in the study group was 29.0±4.58 and in the control group 29.2±4.29 (p = 0.801). The level of interleukin IL1B was considerably increased in the study group L1 with an average of 1044.67±125.79 pg/ml and in the control group L0 it was 354.32±70.98 pg/ml, p<0.001. The mean level of anti-inflammatory interleukin IL10 in L1 was 186.06±30.71 pg/ml and in L0 186.93±34.26 pg/ml, p = 0.897. Conclusion. Endometrial immune status in patients with primary infertility is characterized by a marked predominance of the Th1 cytokine profile, supporting significant levels of proinflammatory cytokines. |
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Cuvinte-cheie primary infertility, endometrium, proinflammatory cytokines, infertilitate primară, endometru, citokine proinflamatorii |
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