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SM ISO690:2012 JERU, Ion, TĂZLĂVAN, Tatiana, DARII, Inga. Particularități patogenice ale cataractei legate de vârstă. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 487. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 487-487 | ||||||
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Background. Age-related cataract is an important cause of blindness and affects 70% of people over the age of 60 years. The pathogenesis of age-related cataract is not completely understood. Objective of the study. The aim of the present study was to determine the concentration of some pro-inflammatory and anti-inflammatory cytokines in the aqueous humor of patients with age-related cataract and arterial hypertension or stable angina pectoris. Material and Methods. A total of 60 patients aged 63 to 70 years who had cataract extraction and recieved an intraocular lens implant were enrolled in the study. The aqueous humor samples (0.1 ml) were obtained during surgery by puncture of the anterior chamber. The concentrations of cytokines in the aqueous humor were measured by using the multiplexed cytokine analysis. Results. Concentration of cytokines in the aqueous humor of patients without comorbidities: IL-1 beta (interleukin-1 beta) - 1.13±0.08 pg/ml, TNF-α (tumor necrosis factor alpha) - 3.77±0.32 pg/ml, IL-1Ra (interleukin-1 receptor antagonist) – 8.72±0.47 pg/ml. Concentration of cytokines in the aqueous humor of patients with arterial hypertension: IL-1 beta – 1.52±0.13 pg/ml, TNF-α – 4.17±0.39 pg/ml, IL-1Ra – 7.84±0.56 pg/ml. Concentration of cytokines in the aqueous humor of patients with stable angina pectoris: IL-1 beta – 1.58±0.11, TNF-α – 4.19±0.38 pg/ml, IL-1Ra – 7.56±0.53 pg/ml. Conclusion. Increased concentration of pro-inflammatory cytokines and decreased concentration of anti-inflammatory cytokines in the aqueous humor may play an important role in the pathogenesis of age-related cataract in patients with arterial hypertension and stable angina pectoris. |
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Cuvinte-cheie age-related cataract, cataractă legată de vârstă |
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