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<identifier identifierType='DOI'>10.5588/ijtld.19.0508</identifier>
<creators>
<creator>
<creatorName>Butov, D.A.</creatorName>
<affiliation>National Medical University of Kharkiv, Ucraina</affiliation>
</creator>
<creator>
<creatorName>Lange, C.</creatorName>
<affiliation>Centrul de Cercetare din Borstel, Germania</affiliation>
</creator>
<creator>
<creatorName>Heyckendorf, J.</creatorName>
<affiliation>Centrul de Cercetare din Borstel, Germania</affiliation>
</creator>
<creator>
<creatorName>Kalmykova, I.M.</creatorName>
<affiliation>Kharkiv Regional Anti-Tuberculosis Dispensary No 1, Kharkiv, Ucraina</affiliation>
</creator>
<creator>
<creatorName>Butova, T.S.</creatorName>
<affiliation>Харьковский национальный университет им. В. Н. Каразина, Ucraina</affiliation>
</creator>
<creator>
<creatorName>Borovok, N.</creatorName>
<affiliation>Kharkiv Regional Anti-Tuberculosis Dispensary No 1, Kharkiv, Ucraina</affiliation>
</creator>
<creator>
<creatorName>Novokhatskaya, M.</creatorName>
<affiliation>Kharkiv Regional Anti-Tuberculosis Dispensary No 1, Kharkiv, Ucraina</affiliation>
</creator>
<creator>
<creatorName>Chesov, D.I.</creatorName>
<affiliation>Centrul de Cercetare din Borstel, Germania</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>Multidrug-resistant tuberculosis in the Kharkiv Region, Ukraine</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2020</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1027-3719</relatedIdentifier>
<subjects>
<subject>management</subject>
<subject>MDR-TB</subject>
<subject>Outcome definitions</subject>
<subject>TBNET</subject>
<subject>Ukraine</subject>
</subjects>
<dates>
<date dateType='Issued'>2020-05-01</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>OBJECTIVE: To document the level of drug resistance in MDR-TB patients and to characterize management capacities for their medical care and MDR-TB treatment outcomes in the Kharkiv region of Ukraine. This area has one of the highest frequencies of MDR-TB worldwide. METHODS: A retrospective observational cohort study was performed on registry data from the regional anti- TB dispensary in Kharkiv. All microbiologically confirmed MDR-TB patients registered in 2014 were included. Diagnostic, treatment and post-treatment follow-up data were analysed. RESULT S: Of 169 patients with MDR-TB, 55.0% had pre-extensively drug-resistant (pre-XDR) or XDR resistant patterns. Rapid molecular diagnosis by GeneXpert and liquid M. tuberculosis cultures were only available for 66.9% and 56.8% of patients, respectively. Phenotypic drug-susceptibility testing (DST) for high priority TB drugs (bedaquiline, linezolid, clofazimine) were not available. DST for later generation fluroquinolones was available only in 53.2% of patients. 50.9% of patients had less than 4 drugs in the treatment regimen proven to be effective by DST. More than 23.1% of patients with MDR-TB failed their treatment and only 45.0% achieved a cure. CONCLUS ION: The high prevalence of MDR-TB and poor MDR-TB treatment outcomes in the Kharkiv region, is associated with substantial shortages in rapid molecular and phenotypic DST, a lack of high priority MDR-TB drugs, poor treatment monitoring and followup capacities.</p></description>
</descriptions>
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