In the recent years, the Republic of Moldova has focused its trade activities, more to West than East. Lately there has been a decisive trend of external policy directed to the integration of the Republic of Moldova with EU. In this paper foreign trade activities of the Republic of Moldova are analyzed. The authors explore the dynamics of foreign trade indicators, the commodity structure of exports and imports and the geography of trade flows, which show the tendency of the gradual shift from CIS market to EU market. Particular attention is also paid to the calculation of indicators for valuation of foreign trade activities, which allow estimating the impact of foreign trade on the country’s economic development. In conclusion, the authors refer to possible negative effect of signing the DCFTA and offer a number of measures to minimize its unfavorable consequences. The present research was realized on selected data and processed by the authors based on statistical yearbooks of the Republic of Moldova, National Bureau of Statistics, and other publications that have served as informational sources specific to researched theme.