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SM ISO690:2012 BOUROSH, Pavlina, STRATULAT, Elena, KORZHA, I., DIZDARI, Anna, GDANIEC, Maria, REVENKO, M., PRISAKARI, Viorel I.. Structure and antimicrobial activity of the copper(II) complex with 8-formylquinoline 4-ethyl-thiosemicarbazone. In: Physical Methods in Coordination and Supramolecular Chemistry, 24-26 octombrie 2012, Chişinău. Chisinau, Republic of Moldova: 2012, XVII, p. 142. |
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Physical Methods in Coordination and Supramolecular Chemistry XVII, 2012 |
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Conferința ""Physical Methods in Coordination and Supramolecular Chemistry"" Chişinău, Moldova, 24-26 octombrie 2012 | |
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Pag. 142-142 | |
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Thiosemicarbazones and their metal complexes are a wide class of biologically active compounds. In the present work, we report the synthesis, structure, and antibacterial property of copper(II) with 8-formilquinoline 4-etylthiosemicarbazone (4-Et-HQATSC). Copper(II) nitrate and 4-Et-HQATSC were dissolved separately in ethanol, and mixed together in equimolar ratio. The final product has the composition Cu(4-Et-HQATSC)(NO3)2. The structure of Cu(4-Et-HQATSC)(NO3)2 is molecular. It consists of discrete molecules in which the coordination sphere is formed by the neutral ligand 4-Et-HQATSC, and two monodentate ions NO3 - , coordinated througth an oxygen atom.schemeIntroduction of ethyl substituent at the nitrogen marginally atom in the thiosemicarbazidic fragment haven’t change the coordination mode of the organic ligand [1]. The base of the tetragonal pyramid is formed by three atoms of the tridentate 4-Et-HQATSC ligand coordinated via NNS donor sites and by one oxygen atom of the nitrate anion. The second NO3 - ion is situated in the apical position. The bond distance Cu-O = 1,994 Å for the ligand coordinated in the equatorial plane is smaller, than interatomic distance Cu-O = 2.431 Å in the apical position. The antimicrobial activity against gram-negative and gram-positive bacteria has been determined for this compound. The results clearly demonstrate than the antibacterial activity of Cu(4-Et-HQATSC)(NO3)2 against Pseudomonas aeruginosa are more than 2 times higher, against Escherichia coli and Enterococcus faecalis 4 times higher, against Proteus vulgaris 64 times higher and against Staphylococcus aureus 12 times higher when compared to the activity of furaciline. The presence of ethyl-substituent in the thiosemicarbazide moiety gives rise to an increasing of the antibacterial activity. |
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