Almost 20 years have elapsed since the research field on Single Molecule Magnets has been opened [1] and from the first pioneering studies performed on solid state systems of molecular origin [2] a huge amount of experiments were carried out on these intriguing systems. [3] The bulk state magnetism was investigated and understood in detail leading to the discovery of some interesting new quantum phenomena. [4-5] Then it was envisaged the organization of those molecules at the nanoscale in order to directly exploit the magnetic properties of the single objects through their assembling on conductive surfaces. It was thus necessary to find suitable techniques to investigate thin films of molecules, selfassembled monolayers of molecules, or even isolated molecules because traditional magnetometric techniques don’t have enough sensitivity to detect signals from such a few amount of active molecules. [6-7] In the presentation it will be shown how synchrotron-based techniques and other high sensitivity techniques can be used to study Single Molecule Magnets at the nanoscale in order to optimize chemical and physical strategies used to assemble those molecules toward the realization of molecular-based devices.