Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
726 4 |
Ultima descărcare din IBN: 2024-03-22 12:55 |
Căutarea după subiecte similare conform CZU |
616-006.6:547:546.56 (1) |
Патология. Клиническая медицина (6964) |
Органическая химия (484) |
Неорганическая химия (450) |
SM ISO690:2012 GARBUZ, Olga. in vitro anticancer activity of chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato) (4-aminobenzene-1-sulfonamide)copper. In: Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii), 2018, nr. 6(116), pp. 70-76. ISSN 1814-3237. |
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Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii) | ||||||
Numărul 6(116) / 2018 / ISSN 1814-3237 /ISSNe 1857-498X | ||||||
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CZU: 616-006.6:547:546.56 | ||||||
Pag. 70-76 | ||||||
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This study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells of lines. It was established, that the copper(II) mixed-ligand complex exhibits the highest anticancer activity against MeW-164, HeLa, BxPC-3 and RD cells of lines with IC50 values of 1.0±0.2, 0.4±0.04, 1.7±0.2, 1.3±0.3 μM, respectively. A comparative study between the tested compound and DOXO in regard to cancer lines has established that the tested copper(II) mixed-ligand complex exhibits stronger inhibitory activity on cancer cells proliferation than doxorubicin and cisplatin. |
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Cuvinte-cheie mixed-ligand complex, doxorubicin, Cisplatin, anticancer activity, cancer cells of line., complex mixt-ligand, doxorubicină, cisplatină, activitate anticancerigenă, linii de celule cancerigene. |
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