Women represent a particularly vulnerable subject of criminal justice, especially because they are victims of sexual and physical violence or suffer from mental illness, depend on alcohol or drugs, come from socially vulnerable segments of the population. These women are socially and economically marginalized and often become victims of abuse by family members or people close to them, victims of sexual and/or physical violence that forces them to commit crimes. Women could become addicted to alcohol or narcotic substances. Recently, global trends indicated an increase in the number of women sentenced to imprisonment. The opposite trend is present in the Republic of Moldova. In the last 5 years, there is a trend in reducing the number of women sentenced to the deprivation of liberty and held in Prison 7 Ruska. In this study, we analyze global tendencies in the women's detention domain, the number of women sentenced to imprisonment in the Republic of Moldova in 2018–2023, the severity of crimes committed and the psychological profile of female prisoners. We determined the trends present within the framework of national justice system and the main problems faced by women deprived of their liberty.