Novel Antioxidants Based on Selected 3d Metal Coordination Compounds with 2-Hydroxybenzaldehyde 4,S-Diallylisothiosemicarbazone

Graur Vasilii О.; Mardari Anastasia; Bourosh Pavlina; Kravtsov Victor; Usataia Irina; Ulchina Ianina; Garbuz Olga; Gulya Aurelian

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2024-04-29 11:53

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GRAUR, Vasilii О., MARDARI, Anastasia, BOUROSH, Pavlina, KRAVTSOV, Victor, USATAIA, Irina, ULCHINA, Ianina, GARBUZ, Olga, GULYA, Aurelian. Novel Antioxidants Based on Selected 3d Metal Coordination Compounds with 2-Hydroxybenzaldehyde 4,S-Diallylisothiosemicarbazone. In: Acta chimica Slovenica, 2023, vol. 70, pp. 122-130. ISSN 1318-0207. DOI: https://doi.org/10.17344/acsi.2022.7885

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Acta chimica Slovenica

Volumul 70 / 2023 / ISSN 1318-0207 /ISSNe 1580-3155

Novel Antioxidants Based on Selected 3d Metal Coordination Compounds with 2-Hydroxybenzaldehyde 4,S-Diallylisothiosemicarbazone

DOI:https://doi.org/10.17344/acsi.2022.7885

Pag. 122-130

Graur Vasilii О., Mardari Anastasia, Bourosh Pavlina, Kravtsov Victor, Usataia Irina , Ulchina Ianina, Garbuz Olga, Gulya Aurelian

Moldova State University

Proiecte:

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Teze de doctorat:

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Disponibil în IBN: 12 aprilie 2023

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2-Hydroxybenzaldehyde 4,S-diallylisothiosemicarbazone (HL) was synthesized and characterized by 1H, 13C NMR and FTIR spectroscopies. It exists in solution in two isomeric forms: cis (~25%) and trans (~75%). Six stable complexes were obtained by interaction of HL with copper(II), nickel(II), cobalt(III) and iron(III) salts: [Cu(L)Cl] (1), [Cu(L)NO3] (2), [Cu(3,4-Lut)(L)NO3] (3), [Ni(L)OAc] (4), [Co(L)2]Cl (5), [Fe(L)2]NO3 (6). The synthesized complexes have been studied by elemental analysis, FTIR, molar electrical conductivity and single crystal X-ray diffraction (6). For all compounds the antioxidant activity against cation radicals ABTS•+ was studied. All complexes and free ligand are more active than trolox that is used in medicine practice. Complex 4 (IC50=7.20µM) is the most active one. The introduction of heterocyclic amine did not improve the antioxidant activity. The introduction of S-allyl group into isothiosemicarbazone affected the activity of the synthesized substances, and in some cases the resulting complexes exhibit greater activity than complexes with isothiosemicarbazones with other S-radicals.

Cuvinte-cheie
antioxidant activity, complexes, crystal structure, isothiosemicarbazone

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