Articolul precedent |
Articolul urmator |
335 2 |
Ultima descărcare din IBN: 2023-03-27 09:58 |
Căutarea după subiecte similare conform CZU |
547-3.057 (1) |
Органическая химия (484) |
SM ISO690:2012 СУКМАН, Наталья. Поиск условий для стереоселективного синтеза спиро[оксиндол-циклопропанов] и оценка их противовирусной активности в отношении вирусов бронзовости томата, тобачной и огуречной мозаики. In: Ştiinţă, educaţie, cultură , Ed. 2022, 11 februarie 2022, Comrat. Comrat, Republica Moldova: Universitatea de Stat din Comrat, 2022, Vol.1, pp. 305-308. ISBN 978-9975-83-176-5; 978-9975-83-177-2. |
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Ştiinţă, educaţie, cultură Vol.1, 2022 |
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Conferința "Ştiinţă, educaţie, cultură" 2022, Comrat, Moldova, 11 februarie 2022 | ||||||
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CZU: 547-3.057 | ||||||
Pag. 305-308 | ||||||
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This paper presents the results of obtaining optically active spiro- [cyclopropane-oxindoles] and studying their anti-HIV activity. Following the testing of many synthesis methods, conditions have been proposed that have allowed to obtain the target compounds with enantioselectivity more than 95% ee. Diastereoselective separation of enantiomers was also performed for some derivatives. The ability of synthesized compounds to inhibit the action of the tobacco mosaic virus- TMV, tomato spotted wilt virus-TSWV and cucumber mosaic virus-CMV has been studied and it has been shown that the hit substances are active at concentrations 0.25%. Keywords: synthesis, spiro[cyclopropane-oxinole], cytotoxicity, antiviral activity, stereoselectivity, diastereoseparation, tobacco mosaic virus, tomato spotted wilt virus, cucumber mosaic virus. |
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Cuvinte-cheie synthesis, spiro[cyclopropane-oxinole], cytotoxicity, antiviral activity, stereoselectivity, diastereoseparation, tobacco mosaic virus, tomato spotted wilt virus, Cucumber mosaic virus |
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