Root rot is among the most widespread and harmful diseases worldwide in various cereal crops, including wheat (Triticum aestivum L.), causing tissue damage to the underground part of the plant, root system, first internode, ability to maintain the plant upright, significant fruit losses (Kaur, 2016; Kiecana et al., 2016; Moya-Elizondo et al., 2011). The genetic method of fighting the disease by creating resistant genotypes is considered a safe and ecologically harmless way of diminishing the consequences of root rot. It should be mentioned, however, that this problem is quite difficult to solve because of the specific of the plant x pathogen species / isolate interaction, which most directly reflects on the variability and heritability of growth traits. The character heritability pattern is important for the plant breeding because it provides information to the extent that a particular character can be transmitted from parent to descendents (Syukur et al., 2012; Bello et al., 2014), and heritability estimation provides information about the level of genetic control of character (Taneva et al., 2019). In relation to the complexity of the systems of factors on which the manifestations of root rot in wheat depend on the growth organs, the purpose of the research was to establish their variability and heritability when interacting with some important pathogens in the initiation and development of the disease – Fusarium oxysporum, F. solani, Drechslera sorokiniana. The work presents data on the action of culture filtrates (CF) of the F. oxysporum, F. solani, D. sorokiniana fungi on the root and strain of 8 common winter wheat genotypes. There were identified: 1) the genotypes with different reaction when treating grains with CF; 2) the share of the genotypic factor in the growth organs reaction to the fungal pathogens; 3) the level of the coefficients of genotypic and phenotypic variation, the coefficient of heritability in the broad sense, the genetic progress for the growth organs in treating the grains with CF of the phytopathogenic fungi. It was concluded that at 5% selection pressure the efficiency of selecting wheat resistant genotypes will be more successful for F. solani and D. sorokiniana. It was concluded that at 5% selection pressure the efficiency of selecting wheat resistant genotypes will be more successful for F. solani and D. sorokiniana.