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<creators>
<creator>
<creatorName>Pantea, V.M.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Sardari, V.V.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Andronache, L.M.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Gamaniuc, M.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Gudumac, V.S.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>Influence of new bioactive compounds on the intensity of the protein metabolism in animals in the blood serum under physiological conditions</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2021</publicationYear>
<relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'>978-9975-3498-7-1</relatedIdentifier>
<subjects>
<subject schemeURI='http://udcdata.info/' subjectScheme='UDC'>577.1:636.084+579.62</subject>
</subjects>
<dates>
<date dateType='Issued'>2021</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Neoplastic diseases continue to be the main focus of the specialists because of their social impact, or cancer is one of the main causes of morbidity and lethality of the worldwide population, which is connected to the imperfection of the used therapeutic means. In this aspect, a special attention deserve the biologically active compounds (CBAs) - new Schiff bases and their coordinative compounds with [3d] metals, which exhibit antiproliferative and cytotoxic properties, exceeding tens and hundreds of times antitumor activity of doxorubicin [Gulea A., et al., 2008; Jalbă S., 2015], but their action on normal tissues is insufficient studied. Based on these considerations, the aim of research was to study the peculiarities of the influence of the new nonplatinum metal coordination compounds (CC) with chelation and macrolydic ligands &ndash; CMA-18, CMA-34, CMD-8, CMG-41, CMJ-33, CMT-67, MG-22, TIA-123, TIA-160 on the intensity of the protein metabolism in the blood serum of the experimental animals under physiological conditions. Biological activity of the CC, was evaluated in experiments on a group of 50 male rats Wistar line, randomly divided into 10 groups. The first group &ndash; control (sham), were injected i/m saline solution daily for 30 days. The experimental animals from groups 2-10 were administered subcutaneously the studied CC three times a week for 30 days: group 2 ‒ CMA-18 (100 nM/kg), group 3 ‒ CMA-34 (1000 nM/kg), group 4 ‒ CMD-8 (100 nM/kg), group 5 ‒ CMG-41 (100 nM/kg), group 6 ‒ CMJ-33 (100 nM/kg), group 7 ‒ CMT-67 (1000 nM/kg), group 8 ‒ MG-22 (100 nM/kg), group 9 ‒ TIA-123 (100 nM/kg) and group 10 ‒ TIA-160 (100 nM/kg). The protein metabolism indices - activity of alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), &gamma;-glutamyl transpeptidase (&gamma;-GTP), pseudocolinesterase (PCE), the content of total proteins, albumin were determined. The study revealed that the functional level of ALAT decreased statistically significant by 23% (p&lt;0,05) under the influence of CMA-18 and by 33% (p&lt;0,01) under the influence of CMJ-33 and the most of the studied CC induced just a discrete decrease tendency. The activity of ASAT practically remained at the level of intact animals, except CMJ-33 which diminished by 9% (p&lt;0,05) its level compared with the control group. Diminished activity of ALAT and ASAT denotes a reduced intensity of protein synthesis. The tested CC did not influence conclusive the levels of total proteins. The content of albumin practically remained at the level of intact animals, except TIA-123 and TIA-160 which decreased statistically conclusive by 14%-15% (p&lt;0,05) and inconclusive decreased by MG- 22 with 13% compared with the control. At the same time activity of &gamma;-GTP, which is the key-enzyme of the &gamma;-glutamyl cycle, responsible for the transport of aminoacids through cell membrane, is basically maintained at the normal levels by CMA-18 and TIA-160, increased statistically significant by 65%-79% under the influence of CMG-41, CMT-67, MG-22 and CMD-8, and exhibits a discrete increase tendency by CMA-34, CMJ-33 and TIA-123. The functional level of PCE increased statistically significantly by 20%-50% after administration of the compounds TIA-123, TIA-160, CMD-8, CMT-67, MG-22, which indicates at the elevated proteosynthetic function of the liver.</p></description>
</descriptions>
<formats>
<format>application/pdf</format>
</formats>
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