| Conţinutul numărului revistei |
| Articolul precedent |
| Articolul urmator |
 677 0 |
 SM ISO690:2012ONIGA, Smaranda Dafina, ARANICIU, Cătălin, MARC, Gabriel, UNCU, Livia, PALAGE, Mariana Doina, ONIGA, Ovidiu. Synthesis, Molecular Docking Studies and Antifungal Activity Evaluation of New Thiazolyl-methylen-1,3,4-oxadiazolines as Potential Lanosterol 14α-demethylase Inhibitors. In: Revista de Chimie, 2019, nr. 10(70), pp. 3522-3526. ISSN 0034-7752. |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
 Revista de Chimie |
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| Numărul 10(70) / 2019 / ISSN 0034-7752 | ||||||
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| Pag. 3522-3526 | ||||||
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| Rezumat | ||||||
Considering the well-established antifungal activity of azole compounds, a new series of thiazolyl-methylen-1,3,4-oxadiazolines derivatives were designed and synthesized as lanosterol-demethylase inhibitors. The final compounds were screened for antifungal activity against the Candida albicans ATCC 90028 strain. Molecular docking studies were performed to investigate the interaction modes between the compounds and the active site of lanosterol 14α-demethylase, which is a target enzyme for anticandidal azoles. Theoretical ADME predictions were also calculated for the final compounds 5a-h. |
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| Cuvinte-cheie 3, 4-oxadiazolines, Candida albicans, Lanosterol 14α-demethylase, Thiazolyl-methylen-1 |
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