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 SM ISO690:2012VLASE, Gabriela, ALBU, Paul, LEDEŢI, Adriana, CIRCIOBAN, Denisa, MURARIU, Marius, CAUNII, Angelica, LEDEŢI, Ionuţ, VLASE, Titus. Thermal behaviour of entacapone, a catechol-O-methyltransferase inhibitor used in Parkinson’s disease. In: Central and Eastern European Conference on Thermal Analysis and Calorimetry, Ed. 4, 28-31 august 2017, Chişinău. Germany: Academica Greifswald, 2017, Editia 4, p. 492. ISBN 978-3-940237-47-7. |
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| Central and Eastern European Conference on Thermal Analysis and Calorimetry Editia 4, 2017 |
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Conferința "Central and Eastern European Conference" 4, Chişinău, Moldova, 28-31 august 2017 | ||||||
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| Pag. 492-492 | ||||||
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in the treatment of Parkinson’s disease in combination with levodopa/carbidopa to treat the symptoms of end-of-dose "wearing-off" effect [1]. Considering that new formulations are researched constantly, proper knowledge of the active pharmaceutical ingredients is crucial in the pre-formulation stages [2]. a b Thermoanalytical curves TG/DTG/HF (a) and UATR spectrum of entacapone (b) In order to fully characterize the analysed compound and determine its thermal behaviour three methods—two integral, (Flynn–Wall–Ozawa, FWO and Kissinger-Akahira-Sunose, KAS) and one differential (Friedman) – were used. The thermoanalytical curves were registered at five different heating rates: β=5, 7, 10, 12 and 15 °C min-1. In order to confirm the purity of the analysed samples, the FTIR spectra entacapone was drawn up and is presented above [3]. |
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