In conditions of intensive agriculture, favorable conditions are created for the spread of the most harmful virus pathogens on the green bean cultures. According to recent observations in the Moscow region, Bean yellow mosaic potivirus (BYMV) and Bean common mosaic potyvirus (BCMV) are economically significant. These viruses cause various pathological changes in plants: deformities, necrosis, dwarfism, oppression of reproductive and photosynthetic organs. This reduces the yield of grain and green bean, worsens the product's quality. The aim of present investigation was to study the isolated viral isolates and to evaluate the prospective varieties of green bean for resistance to the most harmful virus pathogens for inclusion in the breeding process. As a result, morphological, physicochemical and biological properties of the isolated BYMV and BCMV isolates were studied. Bean yellow mosaic potyvirus during mechanical inoculation of indicator plants caused various systemic symptoms on plants of fenugreek (Trigonella), pea, bean, sweet pea, vigna. BYMV virions had a spherical shape with a diameter of 30 nm. When Bean isolate common mosaic potyvirus infected indicator plants, only green bean plants were sensitive. The BCMV virions had a spherical shape with a diameter of 35 nm. The collection nursery of the green bean FSBSI FSVC is annually supplemented with varieties of Russian and foreign selection for evaluation of resistance to viral infection and their inclusion in the breeding process. The study of the stability of the collection and breeding material of green bean to BYMV and BCMV is conducted in dynamics on a natural provocative infectious background, where the degree of defeat of susceptible samples annually ranges from 50% to 100%. For selection, the most interesting are samples without signs of virus damage by pathogens throughout the growing season in different years. As sources of complex resistance to viral infections, in combination with high economic-value traits from the collection nursery, samples of Perun, Khavskaya universal′naya, Mirage, Irishka, Zolotoy nektar, Fartran, Vestochka, Zolotaya sheyka, Kiritsia, Nota are highlighted. These samples were included in hybridization to produce resistant green bean varieties to Bean yellow mosaic potyvirus and Bean common mosaic potyvirus.