Azerbaijan is located in the South Caucasus, which is considered as one of the centers of biodiversity in the world. The rich diversity of plant species that grow on the territory of the republic is represented by 4500 species, which is about 64% of the flora of the Caucasus and 11% of the flora of our planet. 209 species of plants of Azerbaijan, representing 32 families and 98 genera, are endemic, of which 547 species are currently threatened with extinction [1]. Features of addressing the issue of conservation and restoration of Azerbaijan plant genetic resources (PGR) have been noted in the National Program for the Biodiversity Conservation (2006), The Low on Azerbaijan PGR (2011), which defined the strategy of conservation, development, and rational use of all the genetic diversity of plant resources at the national level and their integration into the world system of natural resources preservation [2].  In order to save the existing unique and valuable diversity of Azerbaijan genetic resources the National Genebank of a medium-term conservation, as well as a zonal network of field genebanks and gene pool gardens, has been in operation at the Genetic Resources Institute since 2004, where collectible samples are constantly kept in an active state and their morphological and physiological, biochemical, immunological, and cytogenetic parameters of life are assessed (3). For the creation of plant genetic resources database we used MS Visual FoxPro computer programming package (4).  The use of biotechnological methods using DNA markers allows determining the degree of genetic diversity of collectible samples, as well as optimizing the composition and number of samples.    At the present, the medium-term storage chamber of the Genetic Resources Institute with a controlled temperature of +5–7°C contains more than 7083 seed samples belonging to 63 families, 244 genera, 437 plant species and 257 subspecies. From them 3740 cereals, 959 legumes, 344 fodders, 655 vegetables, 932 technical crops, 69 fruits and 375 are medicinal plants. It is planning to transfer the samples from medium-term conservation to long-term conservation in a near future. Over set periods of storage, the seed material is subjected to restoration and regeneration. Information accumulated in all of the stages of collection, conservation and restoration is documented and placed into a central database CDB, which contains information on 11962 samples belonging to 113 families, 443 genera, 869 plant species and 304 subspecies. From them 4368 cereals, 1208 legumes, 737 fodders, 865 vegetables, 1580 technical crops, 2414 fruits and 786 medicinal plants. At the CDB 4508 scientific-breeding materials, 2365 landraces, 3025 research materials, 2056 wild relatives, 8 others has been classificated. From them 3134 scientific-breeding materials, 631 landraces, 2397 research materials, 915 wild relatives and 6 other plants are at the medium term conservation.   In 2011–2015 years seeds from the national collection in the amount of 1722 samples were sent by the National Genebank of Azerbaijan to the “Svalbard Global Seed Vault” and also to other international genebanks for duplication of samples.