Non additive genetic component that is the base of a quantitative character has no predictability, this is the reason for which the present paper is proposing to appreciate the special combinatory capacity for metabolic profile, in a specific crossing scheme combining three rabbit breeds common in Timis county breeders New Zealand White, Large Chinchilla and Californian. Biochemical analysis of the metabolic profile did not record differences between hybrids and pure bred individuals. The crossing scheme is recommended for producing meat individuals destined for slaughterhouses. This scheme provides an exploitation of the high fervency of the heterozygote at maternal forms and at the final hybrids.