Disfuncţia endotelinică a arterei pulmonare în hipertensiune arterială pulmonară

Popovici Mihail; Nalivaico Oxana; Todiraş Mihail; Cobeţ Valeriu; Ciobanu Nicolae; Ivanov Victoria; Ciobanu Lucia; Popovici Ion

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2022-07-13 16:47

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POPOVICI, Mihail, NALIVAICO, Oxana, TODIRAŞ, Mihail, COBEŢ, Valeriu, CIOBANU, Nicolae, IVANOV, Victoria, CIOBANU, Lucia, POPOVICI, Ion. Disfuncţia endotelinică a arterei pulmonare în hipertensiune arterială pulmonară. In: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale, 2006, nr. 2(6), pp. 142-144. ISSN 1857-0011.

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Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale

Numărul 2(6) / 2006 / ISSN 1857-0011

Disfuncţia endotelinică a arterei pulmonare în hipertensiune arterială pulmonară

Pag. 142-144

Popovici Mihail, Nalivaico Oxana, Todiraş Mihail, Cobeţ Valeriu, Ciobanu Nicolae, Ivanov Victoria, Ciobanu Lucia, Popovici Ion

IMSP Institutul de Cardiologie

Disponibil în IBN: 29 noiembrie 2013

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Reactivitatea endotelinică in vitro a arterei pulmonare s-a evaluat la 17 pacienţi cu hipertensiune arterială pulmonară (46,29±2,17 mm Hg), datele fiind comparate cu indicii arterei pulmonare preluate de la 12 pacienţi fără HAP (22,92±0,65). Răspunsul constrictor al vasului a fost semnificativ crescut în HAP ( 20-21%) la acţiunea ET-1 (1,0 nM sau 10,0 nM), ce s-a atenuat concludent, până la valori referinţă, la inhibiţia receptorilor ETA prin pretratarea acţiunii ET-1 în concentraţia joasă cu antagonistul BQ-123. Inhibiţia receptorilor ETB prin Q-788 a determinat o creştere de circa 3 ori mai slabă a constricţiei endotelinice în HAP, sugerând afectarea receptorilor ETB endotelinici.

The in vitro endothelial reactivity of the pulmonary artery was evaluated on 17 patients with pulmonary arterial hypertension (46,29±2,17 mm Hg) the data have being compared with indices of pulmonary artery taken from 12 pts without PAH. The vascular constrictor response to ET-1 action (1,0 nM or 10,0 nM) was significantly increased in PAH, which had become blunted up to control value in the pretreatment of low ET-1 concentration with ETA antagonist, BQ-123. The ETB receptor inhibition with BQ-788 led to a 3-times less enhancement of endothelinic constriction suggesting the endothelial ETB receptor disability.

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