Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues

Carbone Marianna; Ciavatta Maria-Letizia; Mathieu Veronique; Ingels Aude; Kiss Robert; Pascale Paola; Mollo Ernesto; Ungur Nikon; Guo Yuewei; Gavagnin M

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CARBONE, Marianna, CIAVATTA, Maria-Letizia, MATHIEU, Veronique, INGELS, Aude, KISS, Robert, PASCALE, Paola, MOLLO, Ernesto, UNGUR, Nikon, GUO, Yuewei, GAVAGNIN, M. Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues. In: Journal of Natural Products, 2017, nr. 5(80), pp. 1339-1346. ISSN 0163-3864. DOI: https://doi.org/10.1021/acs.jnatprod.6b00941

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Journal of Natural Products

Numărul 5(80) / 2017 / ISSN 0163-3864

Marine Terpenoid Diacylguanidines: Structure, Synthesis, and Biological Evaluation of Naturally Occurring Actinofide and Synthetic Analogues

DOI:https://doi.org/10.1021/acs.jnatprod.6b00941

Pag. 1339-1346

Carbone Marianna¹, Ciavatta Maria-Letizia¹, Mathieu Veronique², Ingels Aude², Kiss Robert², Pascale Paola¹, Mollo Ernesto¹, Ungur Nikon³, Guo Yuewei⁴, Gavagnin M¹

¹ Institute of Biomolecular Chemistry, Pozzuoli,
² Free University of Brussels,
³ Institute of Chemistry of the Academy of Sciences of Moldova,
⁴ Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Disponibil în IBN: 21 februarie 2018

Rezumat

A new diacylguanidine, actinofide (1), has been isolated from the marine mollusk Actinocyclus papillatus. The structure, exhibiting a guanidine moiety acylated by two terpenoid acid units, has been established by spectroscopic methods and secured by synthesis. Following this, a series of structural analogues have been synthesized using the same procedure. All of the compounds have been evaluated in vitro for the growth inhibitory activity against a variety of cancer cell lines.

Cuvinte-cheie
animals, Cell Line, tumor, Drug Screening, Humans, molecular structure, Mollusca, Structure-Activity Relationship, Terpenes,

Assays, guanidine,

Antitumor

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