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<identifier identifierType='DOI'>10.1111/php.12772</identifier>
<creators>
<creator>
<creatorName>Miller, S.</creatorName>
<affiliation>Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Statele Unite ale Americii</affiliation>
</creator>
<creator>
<creatorName>Coelho, S.</creatorName>
<affiliation>National Institute on Aging, National Institutes of Health, Bethesda, Statele Unite ale Americii</affiliation>
</creator>
<creator>
<creatorName>Yamaguchi, Y.</creatorName>
<affiliation>IMSP Institutul Oncologic, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Hearing, V.</creatorName>
<affiliation>National Institute on Aging, National Institutes of Health, Bethesda, Statele Unite ale Americii</affiliation>
</creator>
<creator>
<creatorName>Beer, J.</creatorName>
<affiliation>Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Statele Unite ale Americii</affiliation>
</creator>
<creator>
<creatorName>De Gruijl, F.</creatorName>
<affiliation>Leiden University, Țările de Jos (Olanda)</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>The Evaluation of Noninvasive Measurements of Erythema as a Potential Surrogate for DNA Damage in Repetitively UV-exposed Human Skin</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2017</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>0031-8655</relatedIdentifier>
<dates>
<date dateType='Issued'>2017-10-01</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Erythema (i.e. visible redness) and DNA damage caused by ultraviolet radiation (UVR) in human skin have similar action spectra and show good correlation after a single exposure to UVR. We explored the potential to use instrumental assessments of erythema as a surrogate for DNA damage after repeated exposures to UVR. We exposed 40 human subjects to three different exposure schedules using two different UVR sources. Cyclobutane-pyrimidine dimers (CPDs) in skin biopsies were measured by immunofluorescence, and erythema was assessed by both the Erythemal Index (EI) and the Oxy-hemoglobin (Oxy-Hb) content. Surprisingly, the skin with the highest cumulative dose ended up with the lowest level of DNA damage, and with the least erythema, as assessed by Oxy-Hb (but not EI) 24 h after the last UV exposure. Although the level of CPDs, on average, paralleled Oxy-Hb (R<sup>2</sup> = 0.80&ndash;0.94, P = 0.03&ndash;0.11), the correlation did not hold for the pooled individual measurements (R<sup>2</sup> = 0.009, P = 0.37) due to potential individual differences in UV-induced photoadaptation. We suggest that the methodology may be optimized to improve the correlation between DNA damage level and erythema to enable noninvasive risk assessment based on erythema/Oxy-Hb content for individual human subjects.</p></description>
</descriptions>
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<format>uri</format>
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