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SM ISO690:2012 PROCA, Nicolae, DANILESCU, Diana, COJUHARI, Maria, BUGOR, Kalina, BURDA, Tatiana. Particularităţi clinice şi paraclinice în ciroza biliară primară. In: Sănătate Publică, Economie şi Management în Medicină , 2014, nr. 5(56), pp. 82-85. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 5(56) / 2014 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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Pag. 82-85 | ||||||
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The aim of the study was to evaluate the clinical and paraclinical particularities in primary biliary cirrhosis (PBC). We performed a retrospective study of 40 patients, hospitalized in the Department of Hepatology: 37 women (92,5%) and 3 men (7,5%), with a mean age of 47 years. Onset of disease was asymptomatic in 10 (25,0%) patients and was manifestated by pruritus in 17 (42,5 %) patients. The most common symptoms of PBC at the time of the examination were: asthenia in 30 (75,0%) patients and pruritus in 22 (55,0%) patients. Hepatomegaly was detected in 34 (85,0%) patients, splenomegaly – in 21 (52,5%) patients and palmar erythema – in 4 (10,0%) patients. Often extrahepatic manifestations were: osteoporosis in 4 patients (10,0%), arthralgia 7 (17,5%) patients and pneumosclerosis in 7 (17,5%) patients. All patients had cholestasis syndrome. Antimitochondrial antibodies were determined in 32 (80,0%) patients, and increased IgM values in 28 (70,0%) patients. |
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Cuvinte-cheie primary biliary cirrhosis, pruritus, antimitochondrial antibodies |
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<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Proca, N.V.</dc:creator> <dc:creator>Danilescu, D.</dc:creator> <dc:creator>Cojuhari, M.</dc:creator> <dc:creator>Bugor, K.</dc:creator> <dc:creator>Burda, T.</dc:creator> <dc:date>2014-10-31</dc:date> <dc:description xml:lang='en'><p><em>The aim of the study was to evaluate the clinical and paraclinical particularities in primary biliary cirrhosis (PBC). We performed a retrospective study of 40 patients, hospitalized in the Department of Hepatology: 37 women (92,5%) and 3 men (7,5%), with a mean age of 47 years. Onset of disease was asymptomatic in 10 (25,0%) patients and was manifestated by pruritus in 17 (42,5 %) patients. The most common symptoms of PBC at the time of the examination were: asthenia in 30 (75,0%) patients and pruritus in 22 (55,0%) patients. Hepatomegaly was detected in 34 (85,0%) patients, splenomegaly – in 21 (52,5%) patients and palmar erythema – in 4 (10,0%) patients. Often extrahepatic manifestations were: osteoporosis in 4 patients (10,0%), arthralgia 7 (17,5%) patients and pneumosclerosis in 7 (17,5%) patients. All patients had cholestasis syndrome. Antimitochondrial antibodies were determined in 32 (80,0%) patients, and increased IgM values in 28 (70,0%) patients.</em></p></dc:description> <dc:description xml:lang='ru'><p><em>Целью исследования было оценить клинические, лабораторные и инструментальные особенности при первичном билиарном циррозе печени (ПБЦ). Было проведено ретроспективное исследование 40 пациентов, госпитализированных в отделение гепатологии: 37 женщин (92,5%) и 3 мужчин (7,5%), средний возраст которых составил 47 лет. У 10 (25,0%) больных начало заболевания было бессимптомным и у 17 (42,5%) заболевание проявлялось кожным зудом. Самыми частыми симптомами ПБЦ были: астения у 30 (75,0%) пациентов и зуд у 22 (55,0%). Гепатомегалия обнаружена у 34 (85,0%) больных, спленомегалия – у 21 (52,5 %), пальмарная эритема – у 4 (10,0%) пациентов. Внепеченочные проявления представлены остеопорозом у 4 (10,0%) больных, болью в суставах – у 7 (17,5 %) и пневмосклерозом – у 7 (17,5%) пациентов. У всех пациентов диагностировали синдром холестаза. У 32 (80,0%) больных были обнаружены антимитохондриальные антитела и у 28 (70,0%) – повышенный уровень иммуноглобулинов класса </em><em>M</em><em> .</em></p></dc:description> <dc:source>Sănătate Publică, Economie şi Management în Medicină 56 (5) 82-85</dc:source> <dc:subject>primary biliary cirrhosis</dc:subject> <dc:subject>pruritus</dc:subject> <dc:subject>antimitochondrial antibodies</dc:subject> <dc:title>Particularităţi clinice şi paraclinice în ciroza biliară primară</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>