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Ultima descărcare din IBN: 2023-02-05 22:31 |
SM ISO690:2012 ŢURCAN, Svetlana. Particularităţi clinico-paraclinice şi abordări noi în diagnosticul şi tratamentul colitei ulceroase. In: Sănătate Publică, Economie şi Management în Medicină , 2014, nr. 5(56), pp. 25-33. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 5(56) / 2014 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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Pag. 25-33 | ||||||
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The aim of the study was to analyze demographic, clinical and biological features of ulcerative colitis and improve diagnostic and treatment schemes based on the risk factors of unfavorable evolution of the disease. Prospective cohort study included: 306 patients with ulcerative colitis with follow-up more than 5 years, 172 – more than 10 years and 79 – more than 15 years. Controlled clinical studies were performed for the comparison of different methods of diagnosis and treatment. For the first time were evaluated epidemiological trends and risk factors of ulcerative colitis in Moldova. Patterns of disease and risk factors for an unfavorable evolution were identified. There was shown a possibility to predict disease evolution. A new method of complete remission diagnosis (by evaluation of markers of the oxidative stress) and a new tactic of maintenance therapy (intermittent treatment) were developed. The most significant risk factors: duration until the specific therapy, therapy at disease onset, duration of remission are modifiable factors, therefore, the adequate and timely treatment can improve the disease prognosis. As a result of integrated approach were developed: classification of disease evolution patterns and treatment algorithm based on the risk factors. |
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Cuvinte-cheie ulcerative colitis, Diagnosis, treatment, risk factors |
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