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![]() SANDUL, Alexandru, MANIUC, Mihail, GUŢULEAC, Ludmila. Unele aspecte histologice, fiziopatologice şi imunologice în comportamentul agresiv al colesteatomului
. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2009, nr. 4(10), pp. 319-321. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 4(10) / 2009 / ISSN 1857-1719 | ||||||
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Pag. 319-321 | ||||||
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Rezumat | ||||||
Some of histological, physiopathological and immunological aspects of aggressive behavior of cholesteatoma
Cholesteatoma are invasive, locally destructive skin-like lesions that, after operative
removal, have a significant recidivistic rate. These aggressive characteristics suggest a
fundamental alteration in the biology of one or more of its constituents ( keratinocytes,
fibroblasts, and inflammatory cells). Although it is generally accepted that destruction and
remodeling of auditive ossicles and temporal bone are mainly caused by the action of
osteoclasts, it has been shown that other constituents also play a role in predigesting the osteoid layer and exposing the mineralized bone to osteoclastic activity. |
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