General Aspects of the Hereditary colorectal polyps in Patients of the Republic of Moldova In the light of the progress achieved in the area of improving the methods of recombined DNA technology, today it has become possible to diagnose a genetic disease, including the Hereditary colorectal polyps as a form of epithelial colorectal neoplasia (ECRN) at the level of genes. To identify the clinical differences between patients with sporadic adenoma from the ones with hereditary neoplasm, genetico-molecular investigations were carried out on a group of patients diagnosed with ECRN. Identification of genetic associations between polymorphous spectra of DNA and the genetic expression was done using the RT-PCR technique.

Datorită progreselor înregistrate în perfectionarea metodelor tehnologiei ADN recombinat, astăzi este posibil diagnosticul unei boli genetice, inclusiv ale polipilor colorectali ereditari, ca formă de neoplazie epitelială colo-rectală(NECR), la nivelul genei. Un lot de pacienţi cu NECR a fost supus unor investigaţii genetico-moleculare, în scopul diferenţierii clinice dintre subiecţii cu adenomi sporadici de cei cu origine ereditară. Identificarea asocierilor genetice dintre spectrele polimorfe de ADN şi expresia genică s-a fost efectuat prin intermediul tehnicii RT-PCR.