Introduction. The progression of hepatic chronic pathological process of HDV etiology is often associated with comorbid gastrointestinal pathology, with progression of the disease. The aim. To study indicators of oxidative stress (OS) in the gastric mucosa (GM) in patients with chronic viral hepatitis (CVH) HDV in dependence on cytolysis syndrome. Material and methods. There were evaluated 12 patients with CVH HDV (F/ M=3/9), age 28.6±2.6, determined cytolysis indicator ALT, an endoscopic examination of the stomach with a biopsy of the GM, performed to evaluate the Helicobacter pylori (HP) degree of infection (DI) and indicators of malondialdehyde (MDA), and the antioxidant superoxide dismutase (SOD) in the GM. Patients were divided into 2 groups depending on the HP DI. Group I with maximum HP DI n=9 (75%), group II with minimal HP DI n=3 (25%). The control group consisted of 15 practically healthy individuals. The work was carried out within the State Program „Chronic liver and pancreatic diseases: nutritional and surgical aspects” 20.80009.8007.37. Results. ALT significant increase was revealed in both groups (244.8±29.0.u/l, 160±14.0 u/l, р≤0.001, р≤0.001, accordingly), against control 20±8 u/l. The gastric mucosa changes were more pronounced in 1 gr, depending on the degree of HP infection: with superficial gastritis in 34% cases, erosive gastritis - 42%, compared to 8% and 16% cases in IIgr, accordingly. The increased MDA levels (24.79±1.2 nmol/L and 22.2±2.1 nmol/L, p≤0.05, р≤0.05, accordingly, compared to control 16.3±1.5 nmol/L) were accompanied with a decrease in SOD in GM in both groups 3.13±0.27 uc/L, 4.08±0.3 uc/L, р≤0.001, р≤0.05, accordingly, against control 5.38±0.4 uc/1gr. Conclusions. In patients with chronic viral hepatitis HDV etiology revealed a direct relationship between the HP infection degree and severity of cytolysis syndrome, accompanied by oxidative stress in the gastric mucosa.