Background. Exacerbations, also known as asthma attacks or acute asthma which occurs when the airways swell and become inflamed. Also defined as the gradual worsening of asthma symptoms, such as coughing, breathing difficulties, and wheezing. Risk factors are something that increases the chance of developing a disease. Respiratory virus infections are the commonest cause of asthma exacerbations: 80-85% of exacerbations among school aged children with asthma are caused by respiratory viruses. Other viral causes of exacerbations include influenza, parainfluenza, coronavirus, adenovirus and human metapneumovirus. Additional risk factors for exacerbations include poor adherence to ICS (especially with over-reliance on short-acting β2-agonists), poor inhaler technique, previous history of exacerbations, poor lung function, smoking, exposure to allergens or pollutants, as well comorbidities including obesity, gastro-esophageal reflux, chronic rhinosinusitis and psychosocial factors. The purpose of the study is to present a clinical case of the patient with identified risk factors of Asthma Exacerbation. Material and Methods. Anamnesis, clinical and paraclinical data were taken from the outpatient registration form and medical records. The patient underwent immunological studies, as well as spirometry study to confirm the diagnosis. Results. A 9-year-old girl was referred to the Institute of Mother and Child Healthcare with complaints of recurrent infections, shortness of breath, runny nose and cough. At the age of 1, the child frequently has ARI, bronchitis, pneumonia. From the age of 8, he has had attacks of suffocation which is mostly seen during physical effort and in wet weather. At 9 years he was diagnosed with bronchial asthma with Ig E 350 IU/ml. At the age of 5 years he had urticaria to ceftriaxone, in September 2022 hives to an antibiotic (the parents do not know which). The family history was positive for atopic dermatitis in older brother. Taking into account the anamnestic data, clinical and para clinical dates, PFT, the diagnosis was confirmed to be persistent moderate bronchial asthma predominantly allergic, with exacerbation along with acute respiratory infections, allergic rhinitis, pneumonia on the right, severe evolution The child was treated with bronchodilators, inhaled and intranasal topical steroids and antihistamines. The severity of disease decreased significantly. Conclusions. Increasing the knowledge of doctors about the disease and risk factors will contribute to earlier diagnosis, earlier initiation of therapy, and will decrease the mortality rate. Here in this case, the factors that contributed to the asthma can be genetics (history of allergy in family), frequent attack of infections, some medications(antibiotics), weather conditions, and physical exertion.