Introduction. Complete mesocolic excision (CME) is a concept in surgical treatment of right colon cancer (RCC) that is set up to improve oncological outcomes. The technique is based on 3 main principles: dissection in the embryological plane, central vascular ligation and resection of a sufficient length of bowel. However, CME is a technically demanding procedure and is not universally adopted due to concerns of higher morbidity. This study aims to analyze the safety of laparoscopic CME colectomy compared to standard colectomy for right-sided colon cancer. Material and Methods. This retrospective study examined 170 patients with RCC treated minim-invasively with radical intent between January 2019 and November 2022 in our Trust. The patients treated by surgeons not performing D3 dissection were excluded from the study. The choice regarding extension of lymphadenectomy was at the operating surgeon discretion. Results. No differences in oncological and clinical characteristics were observed between the CME and standard right colectomy groups. Also, no statistical differences were shown in terms of blood loss, intraoperative complications, conversion rate, and operative time. The postoperative morbidity rate (Clavien-Dindo grade III-IV) was 9.77% in conventional surgery group and 4.87% in CME group. The number of lymph nodes harvested was significantly higher in the CME group (27 vs. 17, P = 0.037). Conclusion. Minim-invasive CME surgery appears safe and does not result in increased complication rates in this single institution cohort. However, further randomised control studies are needed to examine long term outcomes.