Introduction. Multimorbidity is a common phenomenon and a big challenge in patients’ families or formal caregivers, however, the available data on the impact of patients' multimorbidity on caregivers are controversial. Material and methods. The study aimed to assess caregivers’ perspectives on the management of multimorbid patients during the COVID-19 pandemic. We conducted 20 semistructured interviews with family members who are in charge of caring for multimorbid patients for at least 5 days a week, for the last 12 months. The caregivers’ opinion was analyzed using a framework analysis approach. Results. In the study were 15 females, and 5 males, and caregiver relationship to the patient's spouse in 7 cases and in 13 cases a family member. The age of the patients with 2 or more chronic conditions was 62,2 ±8.7 years old, while their caregivers were 57±10.2 years old. All the caregivers reported an increased degree of stress and uncertainty during the pandemic. They were concerned about access to medical services, or the availability of necessary medication for their relatives. The limitation of carrying out the daily routine worsened the patient’s health status in 40% of cases, and they fill more susceptible to dependency and vulnerability. Also, more than 60% of caregivers mentioned problems managing finances, caring for others family members especially children, and supplementary home obligations during the lockdown. Conclusions. During the COVID-19 pandemic caregivers’ burden was high amongst families of multimorbidity patients and the challenges targeted all studied domains.