Introduction. The World Health Organization (WHO) battles the burden of non-communicable diseases (NCDs) associated to obesity, recently intensified by the COVID-19 pandemic. The increase of obesity rate overwhelms the resources of the medical system due to inefficient treatment of its accompanying NCDs, overseeing the primary lifestyle issue. The aim of research was to identify the correlation between obesity and sedentary lifestyle to the non-communicable diseases (NCDs) development and severity of COVID-19 complications in the context of improvement of health resources. Material and Methods. It was performed a systematic review of data regarding the development of the Covid-19 infection in patients with NCDs provided by BMC and WHO (between 01.03.2020- 01.03.2021), and scientific articles related to obesity published in PubMed database (2008-2021). At the end of the selection process, 15 articles were selected for use in the literature review. Results. In the context of the COVID-19 pandemic, obesity (BMI= ≥30 kg/m 2) has become a morbidity of high risk. The mortality rate reaches about 4 million deaths yearly, implying cardiovascular, endocrine, chronic respiratory diseases and other conditions. On the background of recent COVID-19 infection targeting its comorbidities, obesity has become more dangerous, with an infection prevalence of 14% to 44% in diabetes patients; 4,7% to 17,5% in hypertension patients, the most prevalent chronic comorbid condition being respiratory pathology (5%). The supervision of obesity according to an elaborate clinical protocol will prevent the increase of the number of patients presenting with NCDs and with severe forms of COVID-19. Conclusions. Due to direct association between obesity and its risks, the early monitoring and lifestyle change in obese patients will minimize the pharmaceutical treatment, resulting in disease reversal, cost reduction and avoidance of invasive treatment.